AJP - Heart pressure measurements
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H2105-H2112, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maeda, S.
Right arrow Articles by Matsuda, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maeda, S.
Right arrow Articles by Matsuda, M.
Vol. 275, Issue 6, H2105-H2112, December 1998

Prolonged exercise causes an increase in endothelin-1 production in the heart in rats

Seiji Maeda1, Takashi Miyauchi2,4, Satoshi Sakai2, Tsutomu Kobayashi2, Motoyuki Iemitsu2, Katsutoshi Goto3,4, Yasuro Sugishita2, and Mitsuo Matsuda1

1 Department of Sports Medicine, Institute of Health and Sport Sciences, 2 Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, 3 Department of Pharmacology, Institute of Basic Medical Sciences, and 4 Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan

Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET-1 in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of ET-1 in the heart was also markedly higher in the exercised rats. Expression of endothelin type A- and type B-receptor mRNA and endothelin-converting enzyme mRNA in the heart did not differ between the groups. The peptide level of ET-1 and the preproET-1 mRNA level in the lungs of the exercised rats did not differ from those in the control rats. The present results show that production of ET-1 is markedly increased tissue specifically in the heart by exercise without appreciable changes in endothelin-converting enzyme and endothelin receptor expression. The present study suggests that myocardial ET-1 may participate in modulation of cardiac function during exercise.

myocardial endothelin-1; positive inotropy; treadmill running; endothelin-converting enzyme; endothelin type A receptor; endothelin type B receptor


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, Y. Kasuya, and T. Miyauchi
Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise
J Appl Physiol, July 1, 2006; 101(1): 151 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Miyauchi, S. Maeda, M. Iemitsu, T. Kobayashi, Y. Kumagai, I. Yamaguchi, and M. Matsuda
Exercise causes a tissue-specific change of NO production in the kidney and lung
J Appl Physiol, January 1, 2003; 94(1): 60 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Iemitsu, T. Miyauchi, S. Maeda, T. Tanabe, M. Takanashi, Y. Irukayama-Tomobe, S. Sakai, H. Ohmori, M. Matsuda, and I. Yamaguchi
Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1750 - H1760.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Iemitsu, T. Miyauchi, S. Maeda, S. Sakai, T. Kobayashi, N. Fujii, H. Miyazaki, M. Matsuda, and I. Yamaguchi
Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2029 - R2036.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. F. Luscher and M. Barton
Endothelins and Endothelin Receptor Antagonists : Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
Circulation, November 7, 2000; 102(19): 2434 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Takamura, R. Parent, P. Cernacek, and M. Lavallee
Influence of dual ETA/ETB-receptor blockade on coronary responses to treadmill exercise in dogs
J Appl Physiol, November 1, 2000; 89(5): 2041 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Iemitsu, T. Miyauchi, S. Maeda, K. Yuki, T. Kobayashi, Y. Kumagai, N. Shimojo, I. Yamaguchi, and M. Matsuda
Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R951 - R959.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online