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Am J Physiol Heart Circ Physiol 276: H326-H332, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 1, H326-H332, January 1999

SPECIAL COMMUNICATION
New simple methods for isolating baroreceptor regions of carotid sinus and aortic depressor nerves in rats

Takayuki Sato1, Toru Kawada1, Hiroshi Miyano1, Toshiaki Shishido1, Masashi Inagaki1, Ryoichi Yoshimura1, Teiji Tatewaki1, Masaru Sugimachi1, Joe Alexander Jr.2, and Kenji Sunagawa1

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan; and 2 Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235

We developed new methods for isolating in situ baroreceptor regions of carotid sinus and aortic depressor nerves in halothane-anesthetized rats. After ligation of the root of the external carotid artery, the internal carotid and pterygopalatine arteries were embolized with two ball bearings of 0.8 mm in diameter. Bilateral carotid sinus pressures were changed between 60 and 180 mmHg in 20-mmHg steps lasting 1 min each. The sigmoidal steady-state relationship between aortic and carotid sinus pressures in 11 rats indicated the maximum gain of the carotid sinus baroreflex to be -2.99 ± 0.75 at 120 ± 5 mmHg. An in situ isolation of the baroreceptor area of the right aortic depressor nerve could be made by ligation of the innominate, common carotid, and subclavian arteries in 9 rats. Pressure imposed on the subclavian baroreceptor was altered between 40 and 180 mmHg in 20-mmHg steps lasting 1 min each. The sigmoidal steady-state relationship between the aortic depressor nerve activity and imposed pressure showed that the baroreceptor gain peaked at 118 ± 4 mmHg. We established an easy approach to the rat baroreflex and baroreceptor research.

gain; feedback system; open-loop conditions; steady state


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