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Am J Physiol Heart Circ Physiol 276: H368-H375, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 2, H368-H375, February 1999

An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs

Cheng-Hsiung Huang, Song-Jung Kim, Bijan Ghaleh, Raymond K. Kudej, You-Tang Shen, Sanford P. Bishop, and Stephen F. Vatner

Cardiovascular and Pulmonary Research Institute, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212

The goal of this study was to determine whether the cardioprotective effects of an A1-receptor agonist and ischemic preconditioning (IPC) involve a shift in the pre-coronary artery occlusion (CAO) spatial distribution of myocardial blood flow, which might shed light on the mechanism of IPC and explain its heterogeneous effects. Accordingly, 60 min of CAO followed by 72 h of coronary artery reperfusion (CAR) was examined in three groups of conscious pigs 10-14 days after instrumentation with aortic and left atrial catheters and coronary artery occluders. Myocardial infarct size, expressed as a fraction of the area at risk (AAR), was reduced significantly (P < 0.05) by infusion of the A1 agonist (27.1 ± 6.6%) and to a greater extent (P < 0.05) by IPC (11.6 ± 5.1%) compared with infarct size in vehicle-treated animals (55.1 ± 2.9%). Transmural myocardial blood flow (radioactive microspheres) in the AAR shifted toward lower levels after infusion of the A1 agonist (1.27 ± 0.19 vs. 0.74 ± 0.10 ml · min-1 · g-1) or IPC (1.27 ± 0.11 vs. 0.96 ± 0.09 ml · min-1 · g-1) but not after infusion of the vehicle (1.20 ± 0.10 vs. 1.23 ± 0.09 ml · min-1 · g-1). This study demonstrated that both pretreatment with an adenosine A1 agonist and also IPC altered the spatial distribution of pre-CAO myocardial blood flow, which might reflect a downregulation of metabolic state and thus play a role in the cardioprotective effects of IPC.

myocardial ischemia; infarction; coronary blood flow; myocardial stunning


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