AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 276: H391-H400, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 2, H391-H400, February 1999

Electrical interactions among real cardiac cells and cell models in a linear strand

Mary B. Wagner1, Takao Namiki1, Ronald Wilders2,3, Ronald W. Joyner1, Habo J. Jongsma2, E. Etienne Verheijck2,3, Rajiv Kumar1, David A. Golod1, William N. Goolsby1, and Antoni C. G. van Ginneken3

1 Todd Franklin Cardiac Research Laboratory, The Children's Heart Center, Department of Pediatrics, Emory University, Atlanta, Georgia 30322; 2 Department of Medical Physiology and Sports Medicine, Utrecht University, 3584 CG Utrecht; and 3 Department of Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

Previous work with model systems for action potential conduction have been restricted to conduction between two real cells or conduction between a model cell and a real cell. The inclusion of additional elements to make a linear strand has allowed us to investigate the interactions between cells at a higher level of complexity. When, in the simplest case of a linear strand of three elements, the conductance between elements 2 and 3 (GC2) is varied, this affects the success or failure of propagation between elements 1 and 2 (coupled by GC1) as well as the success or failure of propagation between elements 2 and 3. Several major features were illustrated. 1) When GC1 was only slightly greater than the coupling conductance required for successful propagation between a model cell and a real cell, addition of a third element of the strand either prevented conduction from element 1 to element 2 (when GC2 was high) or allowed conduction from element 1 to element 2 but not conduction from element 2 to element 3 (when GC2 was low). 2) For higher levels of GC1, there was an allowable "window" of values of GC2 for successful conduction from element 1 through to element 3. The size of this allowable window of GC2 values increased with increasing values of GC1, and this increase was produced by increases in the upper bound of GC2 values. 3) When the size of the central element of the strand was reduced, this facilitated conduction through the strand, increasing the range of the allowable window of GC2 values. The overall success or failure of conduction through a structure of cells that has a spatially inhomogeneous distribution of coupling conductances cannot be predicted simply by the average or the minimum value of coupling conductance but may depend on the actual spatial distribution of these conductances.

coupling conductance; cardiac action potential conduction


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