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1 Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Parc Scientifique d'Ecublens, 1015 Lausanne, Switzerland; 2 Hydraulics Laboratory, Institute Biomedical Technology, University of Gent, Gent, Belgium; and 3 Laboratory for Physiology, Institute for Cardiovascular Research, Institute for Cardiovascular Research, Free University, Amsterdam, The Netherlands
We determined total arterial compliance from
pressure and flow in the ascending aorta of seven anesthetized dogs
using the pulse pressure method (PPM) and the decay time method (DTM).
Compliance was determined under control and during occlusion of the
aorta at four different locations (iliac, renal, diaphragm, and
proximal descending thoracic aorta). Compliance of PPM gave
consistently lower values (0.893 ± 0.015) compared with the
compliance of DTM (means ± SE; r = 0.989). The lower compliance estimates by the PPM can be attributed to
the difference in mean pressures at which compliance is determined
(mean pressure, 81.0 ± 3.6 mmHg; mean diastolic pressure, over
which the DTM applies, 67.0 ± 3.6 mmHg). Total arterial compliance
under control conditions was 0.169 ± 0.007 ml/mmHg.
Compliance of the proximal aorta, obtained during occlusion of the
proximal descending aorta, was 0.100 ± 0.007 ml/mmHg.
Mean aortic pressure was 80.4 ± 3.6 mmHg during control and 102 ± 7.7 mmHg during proximal descending aortic occlusion. From these
results and assuming that upper limbs and the head contribute as little
as the lower limbs, we conclude that 60% of total arterial compliance
resides in the proximal aorta. When we take into account the inverse
relationship between pressure and compliance, the contribution of the
proximal aorta to the total arterial compliance is even more significant.
aortic occlusion; proximal aorta; dog; decay time method
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