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Am J Physiol Heart Circ Physiol 276: H429-H437, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 2, H429-H437, February 1999

Synchrotron microangiography reveals configurational changes and to-and-fro flow in intramyocardial vessels

Hidezo Mori1, Etsuro Tanaka1, Kazuyuki Hyodo2, Minhaz Uddin Mohammed1, Takafumi Sekka1, Kunihiksa Ito1, Yoshiro Shinozaki1, Akira Tanaka1, Hiroe Nakazawa1, Sumihisa Abe1, Shunnosuke Handa1, Misao Kubota3, Kenkichi Tanioka3, Keiji Umetani4, and Masami Ando2

1 Departments of Physiology, Internal Medicine, and Surgery, Tokai University School of Medicine, Isehara 259-1193; 2 National Laboratory for High Energy Physics, Tsukuba 305-0801; 3 Nippon Hoso Kyokai Science and Technical Research Laboratories, Tokyo 157-8510; 4 Japan Synchrotron Radiation Research Institute, Hyogo 675-5198, Japan

In 8 dogs, in situ microangiography using synchrotron radiation visualized penetrating transmural arteries (PTAs) with a diameter of >60 µm and allowed quantitation of vessel diameters of >140 µm. Myocardial contraction reduced the vascular short-axial diameters to 87 ± 17% (n = 62, P < 0.001, paired t-test) of the end-diastolic values and increased the longitudinal dimension to 129 ± 5% (n = 45, P < 0.001). The diameter reduction in the subendocardial PTA segments was significantly more marked than that in the subepicardial PTA segments (60 ± 12 vs. 88 ± 12%, n=13, P < 0.001, paired t-test). Intracoronary administration of dobutamine (0.1 µg · kg-1 · min-1) increased, and in contrast, partial clamping of the coronary artery (ischemia) decreased, the configurational changes. To-and-fro blood flow was clearly observed in PTAs with visual identification of capacitive backflow, resistive forward flow during ischemia on coronary arteriography, and even under baseline conditions in coronary venography. Thus this method advances our understanding of mechanical influences on the coronary circulation.

coronary artery; myocardial blood flow; synchrotron radiation; angiography


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