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Am J Physiol Heart Circ Physiol 276: H658-H662, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 2, H658-H662, February 1999

Effect of estrogen on aortic function in postmenopausal women

Christodoulos Stefanadis, Eleftherios Tsiamis, John Dernellis, and Pavlos Toutouzas

Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece

We hypothesized that estrogen may alter aortic elastic properties. The aortic pressure-diameter relation was obtained in 20 postmenopausal women, 10 without (group 1) and 10 with (group 2) proven coronary artery disease, before and after intravenous administration of 10 µg of 17beta -estradiol. Instantaneous aortic diameter was measured by an intravascular catheter developed in our institution simultaneously with aortic pressure at the same aortic level with a catheter-tipped micromanometer. At baseline, elastic properties of the aorta were decreased in group 2 compared with group 1. Compared with baseline, aortic distensibility was increased in both groups (P < 0.01 and P < 0.05 for groups 1 and 2, respectively) after estrogen administration, whereas the pressure-diameter loop was shifted downward along a different hypothetical line of elasticity, suggesting active changes in the aortic elastic properties. Furthermore, a significant reduction in wave reflection was found in both groups (P < 0.001). This action may contribute to the beneficial effects of estrogen on the cardiovascular system and may have future therapeutic implications in postmenopausal women.

aortic pressure-diameter relation; distensibility; wave reflections; 17beta -estradiol


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