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Section of Hypertension and Vascular Research, University of Texas Medical Branch, Galveston, Texas 77555-1065
We recently described a perivascular sensory
nerve-linked dilator system that can be activated by interstitial
Ca2+
(Ca2+isf). The present study tested the
hypothesis that Ca2+isf in the rat
duodenal submucosa varies through a range that is sufficient to
activate this pathway. An in situ microdialysis method was used to
estimate Ca2+isf. When the duodenal lumen
was perfused with Ca2+-free
buffer, Ca2+isf was 1.0 ± 0.13 mmol/l. Ca2+isf increased to 1.52 ± 0.04, 1.78 ± 0.10, and 1.89 ± 0.1 when the lumen was perfused
with buffer containing 3, 6, and 10 mmol/l Ca2+, respectively
(P < 0.05).
Ca2+isf was 1.1 ± 0.06 mmol/l in
fasted animals and increased to 1.4 ± 0.06 mmol/l in free-feeding
rats (P < 0.05). Wire myography was
used to study isometric tension responses of isolated mesenteric
resistance arteries. Cumulative addition of extracellular
Ca2+-relaxed serotonin- and
methoxamine-precontracted arteries with half-maximal effective doses of
1.54 ± 0.05 and 1.67 ± 0.08 mmol/l, respectively
(n = 5). These data show that duodenal
Ca2+isf undergoes dynamic changes over a
range that activates the sensory nerve-linked dilator system and
indicate that this system can link changes in local
Ca2+ transport with alterations in
regional resistance and organ blood flow.
calcium; interstitium; microdialysis; vascular reactivity; calcium receptor; duodenum
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