AJP - Heart AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 276: H1049-H1057, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zellner, C.
Right arrow Articles by Sudhir, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zellner, C.
Right arrow Articles by Sudhir, K.
Vol. 276, Issue 3, H1049-H1057, March 1999

Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries

Christian Zellner1, Andrew A. Protter2, Eitetsu Ko1, Madhusudhan R. Pothireddy1, Teresa DeMarco1, Stuart J. Hutchison1, Tony M. Chou1, Kanu Chatterjee1, and Krishnankutty Sudhir3

1 The Vascular Research Laboratory, Division of Cardiology, University of California at San Francisco, San Francisco 94143-0124; 2 Scios Incorporated, Mountain View, California 94043; and 3 The Hormones and Vasculature Laboratory, Baker Institute, Melbourne, Victoria 3181, Australia

Brain natriuretic peptide (BNP), a hormone secreted predominantly in ventricular myocytes, may influence coronary vascular tone. We studied the coronary vasodilatory response to BNP under physiological conditions and after preconstriction with endothelin-1 (ET-1) in anesthetized pigs. Average peak-flow velocity (APV) was measured using intracoronary Doppler, and cross-sectional area (CSA) was measured using intravascular ultrasound. Coronary blood flow (CBF) was calculated. Intracoronary BNP induced dose-dependent increases in CSA, APV, and CBF similar in magnitude to those induced by nitroglycerin (NTG). The magnitude of BNP-induced vasodilation was accentuated after preconstriction with ET-1. Pretreatment with either the nitric oxide synthase inhibitor Nomega -nitro-L-arginine methyl ester or the cyclooxygenase inhibitor indomethacin attenuated the coronary vasodilator effect of BNP in resistance arteries without influencing epicardial vasodilation. Pretreatment with the ATP-sensitive potassium-channel blocker glibenclamide enhanced epicardial vasodilation in response to BNP. We conclude that BNP exerts coronary vasodilator effects, predominantly in epicardial conductance vessels. An accentuated vasodilatory response to BNP occurs in ET-1-preconstricted arteries. BNP-induced vasodilation in coronary resistance arteries may be partially mediated via nitric oxide and/or prostaglandin release.

brain natriuretic peptide; vascular reactivity; pig; endothelin-1; Nomega -nitro-L-arginine methyl ester; indomethacin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Belluardo, A. Cataliotti, L. Bonaiuto, E. Giuffre, E. Maugeri, P. Noto, G. Orlando, G. Raspa, B. Piazza, L. Babuin, et al.
Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1529 - H1535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Chen, J. H. Traverse, M. Hou, Y. Li, R. Du, and R. J. Bache
Effect of PDE5 inhibition on coronary hemodynamics in pacing-induced heart failure
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1513 - H1520.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. P. D'Souza, D. M. Yellon, C. Martin, R. Schulz, G. Heusch, A. Onody, P. Ferdinandy, and G. F. Baxter
B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1592 - H1600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online