| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas 78712
The aim of this
study was to determine the effects of acute bouts of exercise on
myocardial recovery after ischemia and heat shock protein
expression. Adult female Sprague-Dawley rats were divided into five
groups: 1) 1-day run (1DR;
n = 6) and
2) 3-day run (3DR;
n = 7), in which rats ran for 100 min
at a speed of 20 m/min up a 6° grade for 1 or 3 consecutive days;
3) 1-day cold run (1CR), in which
rats ran the same as 1DR but with wet fur at 8°C, which prevented
an elevation of core temperature (n = 8); 4) heat shock sedentary (HS), in
which rats had their core temperatures raised to 42°C one time for
15 min (n = 5); and
5) sedentary control
(n=15). Cardiac function was analyzed
24 h after the last treatment using an isolated, working heart model.
Nonpaced hearts were initially perfused under normoxic conditions, then underwent 17 min of global, normothermic (37°C) ischemia,
and, finally, were allowed to recover for 30 min under normoxic
conditions. The concentration of the 72-kDa heat shock protein (HSP 72)
was measured in each left ventricle. Compared with that in the
sedentary group, recovery of cardiac output × systolic pressure
(CO × SP) was enhanced (P < 0.05) in all treatment groups when the postischemic value was covaried
with the preischemic value. No differences in CO × SP were found
(P > 0.05) between the following
groups: 1DR vs. 3DR, 1DR vs. HS, and 1DR vs. 1CR. Heat shock protein
concentration was significantly greater
(P < 0.05) than that in the
sedentary controls in HS, 1DR, and 3DR groups, but not for 1CR. The
concentration of HSP 72 was not significantly correlated with
postischemic CO × SP
(R2 = 0.197, P > 0.05). We conclude that acute
bouts of exercise can produce cardioprotective effects without an
elevation of HSP 72.
myocardium; ischemia-reperfusion; rat; perfused heart; hemodynamics
This article has been cited by other articles:
|
|
 |
|
  J. L. Staib, N. Tumer, and S. K. Powers Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heart Exp Physiol, January 1, 2009; 94(1): 71 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Kavazis, J. M. McClung, D. A. Hood, and S. K. Powers Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H928 - H935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brown, M. S. Johnson, C. J. Armstrong, J. M. Lynch, N. M. Caruso, L. B. Ehlers, M. Fleshner, R. L. Spencer, and R. L. Moore Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol, December 1, 2007; 103(6): 1979 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Brown and R. L. Moore Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise J Appl Physiol, November 1, 2007; 103(5): 1894 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Whitham, S. J. Laing, A. Jackson, N. Maassen, and N. P. Walsh Effect of exercise with and without a thermal clamp on the plasma heat shock protein 72 response J Appl Physiol, October 1, 2007; 103(4): 1251 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Quindry, K. L. Hamilton, J. P. French, Y. Lee, Z. Murlasits, N. Tumer, and S. K. Powers Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis J Appl Physiol, September 1, 2007; 103(3): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Thorp, J. V. Haist, J. Leppard, K. J. Milne, M. Karmazyn, and E. G. Noble Exercise training improves myocardial tolerance to ischemia in male but not in female rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R363 - R371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Staib, J. C. Quindry, J. P. French, D. S. Criswell, and S. K. Powers Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R432 - R439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Taylor, M. E. Olsen, and J. W. Starnes Improved postischemic function following acute exercise is not mediated by nitric oxide synthase in the rat heart Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H601 - H607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Chicco, D. S. Hydock, C. M. Schneider, and R. Hayward Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity J Appl Physiol, February 1, 2006; 100(2): 519 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Reger, M. F. Barbe, M. Amin, B. F. Renna, L. A. Hewston, S. M. MacDonnell, S. R. Houser, and J. R. Libonati Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension J Appl Physiol, February 1, 2006; 100(2): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hwang, P. J. Reiser, and G. E. Billman Effects of exercise training on contractile function in myocardial trabeculae after ischemia-reperfusion J Appl Physiol, July 1, 2005; 99(1): 230 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lennon, J. C. Quindry, K. L. Hamilton, J. P. French, J. Hughes, J. L. Mehta, and S. K. Powers Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H975 - H980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lennon, J. Quindry, K. L. Hamilton, J. French, J. Staib, J. L. Mehta, and S. K. Powers Loss of exercise-induced cardioprotection after cessation of exercise J Appl Physiol, April 1, 2004; 96(4): 1299 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Brown, K. N. Jew, G. C. Sparagna, T. I. Musch, and R. L. Moore Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart J Appl Physiol, December 1, 2003; 95(6): 2510 - 2518. [Abstract] [Full Text]
|
|
|
|
|
|
H. A. Demirel, K. L. Hamilton, R. A. Shanely, N. Tumer, M. J. Koroly, and S. K. Powers Age and attenuation of exercise-induced myocardial HSP72 accumulation Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1609 - H1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Harris, M. A. Blackstone, H. Ju, V. J. Venema, and R. C. Venema Heat-induced increases in endothelial NO synthase expression and activity and endothelial NO release Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H333 - H340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Starnes, R. P. Taylor, and Y. Park Exercise improves postischemic function in aging hearts Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H347 - H351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Mitchell, M. B. Harris, A. R. Cordaro, and J. W. Starnes Effect of body temperature during exercise on skeletal muscle cytochrome c oxidase content J Appl Physiol, August 1, 2002; 93(2): 526 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Milne and E. G. Noble Exercise-induced elevation of HSP70 is intensity dependent J Appl Physiol, August 1, 2002; 93(2): 561 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Patel, A. Hsu, and G. J. Gross Attenuation of heat shock-induced cardioprotection by treatment with the opiate receptor antagonist naloxone Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2011 - H2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Demirel, S. K. Powers, M. A. Zergeroglu, R. A. Shanely, K. Hamilton, J. Coombes, and H. Naito Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat J Appl Physiol, November 1, 2001; 91(5): 2205 - 2212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Jew and R. L. Moore Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats J Appl Physiol, October 1, 2001; 91(4): 1545 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hamilton, S. K. Powers, T. Sugiura, S. Kim, S. Lennon, N. Tumer, and J. L. Mehta Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1346 - H1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Harris and J. W. Starnes Effects of body temperature during exercise training on myocardial adaptations Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2271 - H2280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Patel, A. Hsu, and G. J. Gross Cardioprotection is strain dependent in rat in response to whole body hyperthermia Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1208 - H1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Paroo, E. S. Dipchand, and E. G. Noble Estrogen attenuates postexercise HSP70 expression in skeletal muscle Am J Physiol Cell Physiol, February 1, 2002; 282(2): C245 - C251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Patel, A. Hsu, and G. J. Gross Attenuation of heat shock-induced cardioprotection by treatment with the opiate receptor antagonist naloxone Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2011 - H2017. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
