AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 276: H998-H1011, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 3, H998-H1011, March 1999

Regulation of energy consumption in cardiac muscle: analysis of isometric contractions

Amir Landesberg and Samuel Sideman

Department of Biomedical Engineering, Julius Silver Institute, Heart System Research Center, Haifa 32000, Israel

The well-known linear relationship between oxygen consumption and force-length area or the force-time integral is analyzed here for isometric contractions. The analysis, which is based on a biochemical model that couples calcium kinetics with cross-bridge cycling, indicates that the change in the number of force-generating cross bridges with the change in the sarcomere length depends on the force generated by the cross bridges. This positive-feedback phenomenon is consistent with our reported cooperativity mechanism, whereby the affinity of the troponin for calcium and, hence, cross-bridge recruitment depends on the number of force-generating cross bridges. Moreover, it is demonstrated that a model that does not include a feedback mechanism cannot describe the dependence of energy consumption on the loading conditions. The cooperativity mechanism, which has been shown to determine the force-length relationship and the related Frank-Starling law, is shown here to provide the basis for the regulation of energy consumption in the cardiac muscle.

calcium control; cooperativity; intracellular; sarcomere


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