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Cardiovascular Center and Departments of Internal Medicine, Psychology, and Pharmacology, University of Iowa, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610
Evidence from
human and animal studies suggests that the arterial chemoreflex may be
exaggerated in essential hypertension. In the present study,
cardiorespiratory responses to peripheral chemoreceptor stimulation
were compared in conscious unrestrained spontaneously hypertensive (SH)
and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats
(13-14 wk old). Chemoreceptors were stimulated by injections of
potassium cyanide (30-125 µg/kg iv). Chemoreceptor stimulation
elicited a pressor response and bradycardia. The peak change in mean
arterial pressure evoked during chemoreceptor stimulation was not
significantly different between SH (n = 18) and WKY (n = 18) rats but was
significantly smaller in SD rats
(n = 18). An evaluation of
respiratory responses to chemoreceptor stimulation in conscious and
anesthetized rats also demonstrated no significant difference between
SH and WKY rats, but the response of the SD rats tended to be smaller.
These results demonstrate that differences in the arterial chemoreflex response of SH vs. normotensive rats are not linked to hypertension but, rather, to differences between rat strains.
cardiovascular; potassium cyanide; arterial chemoreceptors; hypertension; spontaneously hypertensive rat
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