AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 276: H1355-H1360, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cagnacci, A.
Right arrow Articles by Volpe, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cagnacci, A.
Right arrow Articles by Volpe, A.
Vol. 276, Issue 4, H1355-H1360, April 1999

Physiological doses of estradiol decrease nocturnal blood pressure in normotensive postmenopausal women

Angelo Cagnacci1, Lucio Rovati2, Annalisa Zanni1, Stefania Malmusi1, Fabio Facchinetti1, and Annibale Volpe1

1 Institute of Obstetrics and Gynecology, University of Modena, 41100 Modena; and 2 Rotta Research Laboratorium Società per Azioni, 20052 Monza, Italy

The effect of a 2-mo treatment with transdermal estradiol (50 µg/day) versus placebo on 24 h of blood pressure rhythm was investigated in 18 normotensive healthy postmenopausal women. Whereas daytime blood pressure was not modified, nighttime blood pressure was reduced by estradiol. Estradiol magnified the nocturnal decrement of systolic (14.3 ± 7.2 vs. 9.8 ± 6.7 mmHg, P = 0.0033), diastolic (11.6 ± 5.0 vs. 7.5 ± 7.3 mmHg, P = 0.028), and mean (10.8 ± 5.6 vs. 7.2 ± 4.5 mmHg, P = 0.011) blood pressure. As a consequence, the 24-h rhythm of mean blood pressure was restored in 50% of the subjects (P = 0.045) in whom it was absent and was amplified in the remaining 50% of the subjects. Body mass index was an independent determinant of blood pressure values being directly related to the amplitude of the 24-h mean blood pressure rhythm (r2 = 0.38; P = 0.0067). In normotensive postmenopausal women, physiological doses of estradiol amplify the nocturnal decline of blood pressure.

circadian; menopause; cardiovascular risk; hypertension


This article has been cited by other articles:


Home page
 J. Physiol.Home page
P. J Fadel, Z. Wang, H. Watanabe, D. Arbique, W. Vongpatanasin, and G. D Thomas
Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy
J. Physiol., December 15, 2004; 561(3): 893 - 901.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. K. Dubey, S. Oparil, B. Imthurn, and E. K. Jackson
Sex hormones and hypertension
Cardiovasc Res, February 15, 2002; 53(3): 688 - 708.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
A. Scuteri, A. J.G. Bos, L. J. Brant, L. Talbot, E. G. Lakatta, and J. L. Fleg
Hormone Replacement Therapy and Longitudinal Changes in Blood Pressure in Postmenopausal Women
Ann Intern Med, August 21, 2001; 135(4): 229 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. S. Pachori, H. Wang, C. H. Gelband, C. M. Ferrario, M. J. Katovich, and M. K. Raizada
Inability to Induce Hypertension in Normotensive Rat Expressing AT1 Receptor Antisense
Circ. Res., June 9, 2000; 86(11): 1167 - 1172.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online