| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Departments of Physiology and
Medicine, Medical College of Virginia at Virginia Commonwealth
University, and Hunter Holmes McGuire Department of Veteran Affairs
Medical Center, Richmond, Virginia 23249;
2 Department of Cardiology and
Cardiovascular Sciences, Fundación Cardiovascular del Oriente
Columbiano, AA 1143 Bucaramanga, Santander, Columbia;
3 Department of Anesthesia, Mayo
Clinic and Foundation, Rochester, Minnesota 55905;
4 Department of Clinical
Physiology,
We evaluated a method of baroreflex testing
involving sequential intravenous bolus injections of nitroprusside
followed by phenylephrine and phenylephrine followed by nitroprusside
in 18 healthy men and women, and we drew inferences regarding human sympathetic and vagal baroreflex mechanisms. We recorded
the electrocardiogram, photoplethysmographic finger arterial pressure,
and peroneal nerve muscle sympathetic activity. We then contrasted
least squares linear regression slopes derived from the depressor
(nitroprusside) and pressor (phenylephrine) phases with
1) slopes derived from spontaneous
fluctuations of systolic arterial pressures and R-R intervals, and
2) baroreflex gain derived from
cross-spectral analyses of systolic pressures and R-R
intervals. We calculated sympathetic baroreflex gain from
integrated muscle sympathetic nerve activity and diastolic pressures.
We found that vagal baroreflex slopes are less when arterial pressures
are falling than when they are rising and that this hysteresis exists
over pressure ranges both below and above baseline levels. Although
pharmacological and spontaneous vagal baroreflex responses correlate
closely, pharmacological baroreflex slopes tend to be lower than those derived from spontaneous fluctuations. Sympathetic baroreflex slopes
are similar when arterial pressure is falling and rising; however,
small pressure elevations above baseline silence sympathetic motoneurons. Vagal, but not sympathetic baroreflex gains vary inversely
with subjects' ages and their baseline arterial pressures. There is no
correlation between sympathetic and vagal baroreflex gains. We
recommend repeated sequential nitroprusside followed by phenylephrine
doses as a simple, efficientmeans to provoke and characterize human
vagal and sympathetic baroreflex responses.
baroreflex gain; hysteresis; muscle sympathetic nerve activity; aging
This article has been cited by other articles:
|
|
 |
|
  K. D. Monahan A new answer to an old question: does ageing modify baroreflex control of vascular sympathetic outflow in humans? J. Physiol., May 1, 2009; 587(9): 1857 - 1857. [Full Text] [PDF]
|
|
|
|
|
|
Pét. Studinger, R. Goldstein, and J. A. Taylor Age- and fitness-related alterations in vascular sympathetic control J. Physiol., May 1, 2009; 587(9): 2049 - 2057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Young, J. P. Fisher, and P. J. Fadel The ups and downs of assessing baroreflex function J. Physiol., March 1, 2008; 586(5): 1209 - 1211. [Full Text] [PDF]
|
|
|
|
|
|
M. Gujic, D. Laude, A. Houssiere, S. Beloka, J.-F. Argacha, D. Adamopoulos, O. Xhaet, J.-L. Elghozi, and P. van de Borne Differential effects of metaboreceptor and chemoreceptor activation on sympathetic and cardiac baroreflex control following exercise in hypoxia in human J. Physiol., November 15, 2007; 585(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kanbar, V. Orea, B. Chapuis, C. Barres, and C. Julien A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1938 - R1946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, S. Durand, and C. G. Crandall Baroreflex control of muscle sympathetic nerve activity during skin surface cooling J Appl Physiol, October 1, 2007; 103(4): 1284 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Wenner, W. C. Rose, E. P. Delaney, M. E. Stillabower, and W. B. Farquhar Influence of plasma osmolality on baroreflex control of sympathetic activity Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2313 - H2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Simmons, J. M. Manson, and J. R. Halliwill Mild central chemoreflex activation does not alter arterial baroreflex function in healthy humans J. Physiol., September 15, 2007; 583(3): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Studinger, R. Goldstein, and J. A. Taylor Mechanical and neural contributions to hysteresis in the cardiac vagal limb of the arterial baroreflex J. Physiol., September 15, 2007; 583(3): 1041 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan, D. J. Dyckman, and C. A. Ray Effect of acute hyperlipidemia on autonomic and cardiovascular control in humans J Appl Physiol, July 1, 2007; 103(1): 162 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan Effect of aging on baroreflex function in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R3 - R12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Simms, J. F. R. Paton, and A. E. Pickering Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats J. Physiol., March 1, 2007; 579(2): 473 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan, U. A. Leuenberger, and C. A. Ray Aldosterone impairs baroreflex sensitivity in healthy adults Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H190 - H197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kamiya, T. Kawada, K. Yamamoto, D. Michikami, H. Ariumi, T. Miyamoto, S. Shimizu, K. Uemura, T. Aiba, K. Sunagawa, et al. Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2641 - H2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Muenter Swift, N. Charkoudian, R. M. Dotson, G. A. Suarez, and P. A. Low Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1226 - H1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Halliwill and C. T. Minson Cardiovagal regulation during combined hypoxic and orthostatic stress: fainters vs. nonfainters J Appl Physiol, March 1, 2005; 98(3): 1050 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Alvarez, J. R. Halliwill, T. P. Ballard, S. D. Beske, and K. P. Davy Sympathetic neural regulation in endurance-trained humans: fitness vs. fatness J Appl Physiol, February 1, 2005; 98(2): 498 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan and C. A. Ray Cyclooxygenase inhibition and baroreflex sensitivity in humans Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H737 - H743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Laitinen, L. Niskanen, G. Geelen, E. Lansimies, and J. Hartikainen Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects J Appl Physiol, June 1, 2004; 96(6): 2333 - 2340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan, I. Eskurza, and D. R. Seals Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2113 - H2117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Parati, M. Di Rienzo, P. Castiglioni, M. Bouhaddi, C. Cerutti, A. Cividjian, J.-L. Elghozi, J.-O. Fortrat, A. Girard, B. J.A. Janssen, et al. Assessing the Sensitivity of Spontaneous Baroreflex Control of the Heart: Deeper Insight Into Complex Physiology * Response Hypertension, May 1, 2004; 43(5): e32 - e34. [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, M. Sato, S. Umehara, and T. Nishikawa Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1091 - R1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Keyl, A. Schneider, A. Gamboa, L. Spicuzza, N. Casiraghi, A. Mori, R. T. Ramirez, F. Leon-Velarde, and L. Bernardi Autonomic cardiovascular function in high-altitude Andean natives with chronic mountain sickness J Appl Physiol, January 1, 2003; 94(1): 213 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Halliwill and C. T. Minson Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans J Appl Physiol, September 1, 2002; 93(3): 857 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Constant, M. Abbas, S. Boucheseiche, D. Laude, and I. Murat Non-invasive assessment of cardiovascular autonomic activity induced by brief exposure to 50% nitrous oxide in children Br. J. Anaesth., May 1, 2002; 88(5): 637 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R252 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, M. Shibasaki, N. A. Hodges, and C. G. Crandall Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans J Appl Physiol, October 1, 2001; 91(4): 1679 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Torp, M. E. Tschakovsky, J. R. Halliwill, C. T. Minson, and M. J. Joyner {beta}-Receptor agonist activity of phenylephrine in the human forearm J Appl Physiol, May 1, 2001; 90(5): 1855 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Iellamo and J. R. G. M. D. H. Groeller Baroreflex control of heart rate during exercise: a topic of perennial conflict J Appl Physiol, March 1, 2001; 90(3): 1184 - 1185. [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Minson, J. R. Halliwill, T. M. Young, and M. J. Joyner Influence of the Menstrual Cycle on Sympathetic Activity, Baroreflex Sensitivity, and Vascular Transduction in Young Women Circulation, February 29, 2000; 101(8): 862 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Halliwill Segregated signal averaging of sympathetic baroreflex responses in humans J Appl Physiol, February 1, 2000; 88(2): 767 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1717 - H1723. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
