AJP - Heart AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 276: H1818-H1826, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hirsch, A. T.
Right arrow Articles by Katz, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirsch, A. T.
Right arrow Articles by Katz, S. A.
Vol. 276, Issue 6, H1818-H1826, June 1999

Active renin and angiotensinogen in cardiac interstitial fluid after myocardial infarction

Alan T. Hirsch3,4, John A. Opsahl1, Mary M. Lunzer4, and Stephen A. Katz1,2

1 Division of Nephrology, Hennepin County Medical Center, Minneapolis 55415; and Departments of 2 Physiology and 3 Medicine and 4 Minnesota Vascular Diseases Center, University of Minnesota Medical School, Minneapolis, Minnesota 55455

The renin-angiotensin system promotes cardiac hypertrophy after myocardial infarction. The purpose of this study was to measure renin and angiotensinogen in plasma and myocardium 10 days after myocardial infarction. Infarction involving 45 ± 4% of left ventricular circumference with accompanying hypertrophy was induced in rats (n = 14). Plasma and myocardial renin were increased after infarction compared with sham controls (n = 8) (27.4 ± 3.2 vs. 7.5 ± 1.8 ng ANG I · ml plasma · h-1, P < 0.0002; and 8.8 ± 1.6 vs. 2.5 ± 0.1 ng ANG I · g myocardium-1 · h-1, P < 0.008, respectively). After infarction, myocardial renin was correlated with infarct size (r = 0.62, P < 0.02) and plasma renin (r = 0.55, P < 0.04). Plasma angiotensinogen decreased in infarct animals, but myocardial angiotensinogen was not different from shams (1.1 ± 0.08 vs. 2.03 ± 0.06 nM/ml plasma, P < 0.002; and 0.081 ± 0.008 vs. 0.070 ± 0.004 nM/g myocardium, respectively). In conclusion, myocardial renin increased after infarction in proportion to plasma renin and infarct size, and myocardial angiotensinogen was maintained after infarction despite decreased plasma angiotensinogen and increased levels of myocardial renin.

renin-angiotensin system; renin glycoforms


This article has been cited by other articles:


Home page
 CirculationHome page
E. Mascareno, M. El-Shafei, N. Maulik, M. Sato, Y. Guo, D. K. Das, and M.A.Q. Siddiqui
JAK/STAT Signaling Is Associated With Cardiac Dysfunction During Ischemia and Reperfusion
Circulation, July 17, 2001; 104(3): 325 - 329.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Saris, F. H. M. Derkx, R. J. A. De Bruin, D. H. W. Dekkers, J. M. J. Lamers, P. R. Saxena, M. A. D. H. Schalekamp, and A. H. Jan Danser
High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin
Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1706 - H1715.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. P. van Kats, D. J. Duncker, D. B. Haitsma, M. P. Schuijt, R. Niebuur, R. Stubenitsky, F. Boomsma, M. A. D. H. Schalekamp, P. D. Verdouw, and A. H. J. Danser
Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade Prevent Cardiac Remodeling in Pigs After Myocardial Infarction : Role of Tissue Angiotensin II
Circulation, September 26, 2000; 102(13): 1556 - 1563.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online