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Am J Physiol Heart Circ Physiol 276: H1839-H1845, 1999;
0363-6135/99 $5.00
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Vol. 276, Issue 6, H1839-H1845, June 1999

Systemic arterial compliance is reduced in young patients with IDDM

Karen L. Berry1, R. Andrew P. Skyrme-Jones1, James D. Cameron2, Richard C. O'Brien3, and Ian T. Meredith1

1 Cardiovascular Centre, Centre for Heart and Chest Research, Monash University and Monash Medical Centre; 3 Diabetes Unit, Monash Medical Centre, Clayton 3168; and 2 Department of Electrical Engineering, Latrobe University, Bundoora, Victoria 3083, Australia

Arterial elastic properties are altered with increasing age and in various disease states, including non-insulin-dependent diabetes mellitus (NIDDM). Whether young patients with insulin-dependent diabetes mellitus (IDDM) have reduced arterial compliance before developing endothelial dysfunction or overt micro- and macrovascular disease is unclear. Systemic arterial compliance and endothelium-dependent, flow-mediated vasodilation (FMD) was assessed in 25 individuals with uncomplicated IDDM (23 ± 4 yr, 14 females and 11 males) and compared with 30 age-matched controls (15 females and 15 males). Arterial compliance was determined via simultaneous measurements of aortic blood flow and carotid arterial pressure. The relationship between arterial compliance and endothelial function (assessed by brachial artery FMD) was also examined. Arterial compliance was 29% lower in IDDM subjects compared with control subjects (0.46 ± 0.05 vs. 0.65 ± 0.07 arbitrary compliance units, P < 0.05). Blood pressure, lipid levels, and daily energy expenditure (a measure of physical activity levels) were not different between groups. Compliance in the IDDM group was not related to the integrity of endothelial vasodilator function, disease duration, or degree of glycemic control. Arterial compliance is reduced in young patients with IDDM before the development of overt micro- or macrovascular disease. Early assessment of arterial compliance may be useful in predicting the development of diabetic vascular complications.

arterial stiffness; diabetes; insulin-dependent diabetes mellitus; endothelium


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