| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan 701; and 2 Department of Physiology, National Yang-Ming University, Medical College, Taipei, Taiwan 11221
This study
attempted to ascertain whether the ischemic damage to neurons and
monoamine overload in brain that occur during rat heatstroke can be
attenuated by heat shock protein (HSP) 72 induction. Effects of
heatstroke on mean arterial pressure (MAP), cerebral blood flow (CBF),
brain dopamine (DA) and serotonin (5-HT) release, and neural damage
score were assayed in rats 0, 16, or 48 h after heat shock (42°C
for 15 min) or chemical stress (5 mg/kg sodium arsenite ip). Brain HSP
72 in rats after heat shock or chemical stress was detected by Western
blot, and brain monoamine was determined by a microdialysis probe
combined with high-performance liquid chromatography. Heatstroke was
induced by exposing the animal to a high ambient temperature
(43°C); the moment at which MAP and CBF decreased from their peak
values was taken as the time of heatstroke onset. Prior heat shock or
chemical stress conferred significant protection against
heatstroke-induced hyperthermia, arterial hypotension, cerebral
ischemia, cerebral DA and 5-HT overload, and neural damage and
correlated with expression of HSP 72 in brain at 16 h. However, at 48 h, when HSP 72 expression returned to basal values, the above responses
that occurred during the onset of heatstroke were indistinguishable
between the two groups (0 h vs. 48 h). These results lead to the
hypothesis that the brain can be preconditioned by thermal or chemical
injury, that this preconditioning will induce HSP 72, and that HSP 72 induction will correlate quite well with anatomic, histochemical, and
hemodynamic protection in rat heatstroke.
microdialysis; heat shock; chemical stress; dopamine; serotonin
This article has been cited by other articles:
|
|
 |
|
  W. C. Lee, H. C. Wen, C. P. Chang, M. Y. Chen, and M. T. Lin Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke J Appl Physiol, June 1, 2006; 100(6): 2073 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Campisi, T. H. Leem, B. N. Greenwood, M. K. Hansen, A. Moraska, K. Higgins, T. P. Smith, and M. Fleshner Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R520 - R530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. H. Chan, K.-F. Chang, C.-C. Ou, and J. Y. H. Chan Up-Regulation of Glutamate Receptors in Nucleus Tractus Solitarii Underlies Potentiation of Baroreceptor Reflex by Heat Shock Protein 70 Mol. Pharmacol., May 1, 2002; 61(5): 1097 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-L. Li, Y.-M. Chao, S. H. H. Chan, and J. Y. H. Chan Potentiation of Baroreceptor Reflex Response by Heat Shock Protein 70 in Nucleus Tractus Solitarii Confers Cardiovascular Protection During Heatstroke Circulation, April 24, 2001; 103(16): 2114 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Kelty, P. A. Noseworthy, M. E. Feder, R. M. Robertson, and J.-M. Ramirez Thermal Preconditioning and Heat-Shock Protein 72 Preserve Synaptic Transmission during Thermal Stress J. Neurosci., January 1, 2002; 22(1): RC193 - RC193. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
