AJP - Heart Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 276: H2204-H2214, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kleiner-Assaf, A.
Right arrow Articles by Elad, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kleiner-Assaf, A.
Right arrow Articles by Elad, D.
Vol. 276, Issue 6, H2204-H2214, June 1999

Hemodynamic model for analysis of Doppler ultrasound indexes of umbilical blood flow

Ayala Kleiner-Assaf1, Ariel J. Jaffa2, and David Elad1

1 Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978; 2 Ultrasound Unit in Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 64239; and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

A hemodynamic model for pulsatile fluid flow in a pressurized thin-walled elastic tube was applied for the computation of volumetric blood flow and velocity profiles for a given set of system parameters at any selected location along the umbilical artery. The velocity profiles over one heart cycle provide the fetal blood flow velocity waveforms (FVW) from which the usual Doppler indexes (DI) can be derived. The model was used for a comprehensive investigation of the correlation between DI and system parameters that reflect the anatomy and physiology of umbilical blood flow. The simulations showed that the radial location of the Doppler measurement is insignificant for the calculated DI, whereas the axial site is important. The analysis showed that decreasing the diameter or increasing the length of the umbilical artery reduces fetal mean blood flow rate and increases the DI. Increasing blood viscosity tends to induce similar patterns, whereas decreasing arterial compliance or increasing blood density decreases the DI with little effect on blood flow rate. Fetal heart rate has a minor effect on both DI and fetal blood flow rate. This study provides insight into the dependence of DI on the anatomic and physiological characteristics of umbilical blood flow.

flow velocity waveform; fetal blood flow; pulsatility index; resistance index


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. H. M. van den Wijngaard, B. E. Westerhof, D. J. Faber, M. M. Ramsay, N. Westerhof, and M. J. C. van Gemert
Abnormal arterial flows by a distributed model of the fetal circulation
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1222 - R1233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Wareing, X. Bai, F. Seghier, C. M. Turner, S. L. Greenwood, P. N. Baker, M. J. Taggart, and G. K. Fyfe
Expression and function of potassium channels in the human placental vasculature
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R437 - R446.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Acharya, T. Erkinaro, K. Makikallio, T. Lappalainen, and J. Rasanen
Relationships among Doppler-derived umbilical artery absolute velocities, cardiac function, and placental volume blood flow and resistance in fetal sheep
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1266 - H1272.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online