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Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan
Within-layer regional myocardial flows in the
left and right ventricles (LV, RV) and in LV with increased myocardial
workload (
1-adrenoceptor
stimulation) were studied transmurally in anesthetized rabbits.
Myocardial flow distribution was visualized with resolutions between
0.1 × 0.1- and 1 × 1-mm2 pixels, using digital
radiography combined with the
3H-labeled desmethylimipramine
deposition technique. The spatial pattern of flow distribution was
quantitated by the coefficient of variation of regional flows (CV,
related to global flow heterogeneity) and the correlation between
adjacent regional flows (CA, inversely related to local flow
randomness). CV was lower in LV than in RV
[P < 0.05, nonparametric 2-way
analysis of variance (NANOVA)]. When resolution was lowered from
0.1 × 0.1- to 1 × 1-mm2 pixels, CV decreased by 70%
in both LV and RV. CA was higher in LV than in RV
(P < 0.05, NANOVA); the
interventricular difference in CA was large over the resolutions
between 0.4 × 0.4- and 1 × 1-mm2 pixels. In LV, both CV and
CA increased with depth of myocardium (P < 0.05, NANOVA); in
subendocardium CV was high comparable with CV in RV
(P = 0.47, NANOVA). The enhancement of
myocardial workload decreased CV and tended to decrease CA in LV
subendocardium (P < 0.05, P = 0.06, respectively; NANOVA). We
conclude that 1) microregional flow
distribution is less heterogeneous and less random in LV than in RV;
2) transmurally, in LV
subendocardium global flow heterogeneity was the highest whereas local
flow randomness was the lowest, so that clusters of low- or high-flow
regions exist in this LV layer; and
3) global flow heterogeneity
decreased and local flow randomness tended to increase (flow
homogenizing occurred) in LV subendocardium with increasing myocardial
workload. Thus the distributed pattern of myocardial microregional
flows may be adaptable to local myocardial metabolic change.
radioactive molecular flow tracer; flow heterogeneity; local flow randomness; coronary vasoregulation
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