| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Adrenergic vasoconstriction in active skeletal muscles
during dynamic exercise
Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295
Sympathetic vasoconstriction in working muscles
during dynamic exercise has been demonstrated by intra-arterial
administration of 
1-adrenergic
antagonists. The purpose of this study was to examine the existence of
1- and
2-adrenergic receptor-mediated vasoconstriction in active skeletal muscles during
exercise. Six mongrel dogs were instrumented chronically
with flow probes on the external iliac arteries of both hindlimbs, and
a catheter was inserted in one femoral artery. All dogs ran on a
motorized treadmill at three exercise intensities (3 miles/h, 6 miles/h, and 6 miles/h at 10% grade) on separate days. After 5 min of
exercise, a selective 1-
(prazosin) or a selective
2-adrenergic antagonist (rauwolscine) was infused as a bolus into the femoral arterial catheter
(only one drug per day). The doses of the antagonists were adjusted to
maintain the same effective concentration at each exercise intensity.
At the mild, moderate, and heavy workloads prazosin infusion produced
immediate increases in iliac conductance of 65 ± 9, 35 ± 6, and 18 ± 4% (means ± SE), respectively, and increases in blood flow of
290 ± 24, 216 ± 23, and 172 ± 18 ml/min, respectively. Rauwolscine infusion produced increases in
conductance of 52 ± 5%, 36 ± 5%, and 26 ± 3%,
respectively, and blood flow increases of 250 ± 34, 244 ± 39, and 259 ± 35 ml/min at the three workloads. Systemic
blood pressure and blood flow in the contralateral iliac artery were
unaffected by any of the antagonist infusions. These results
demonstrate that there is ongoing
1- and
2-adrenergic receptor-mediated
vasoconstriction in exercising skeletal muscles even at heavy workloads
and that the magnitude of vasoconstriction decreases as exercise
intensity increases.
blood flow; sympathetic nervous system; 2-adrenergic receptor; rauwolscine; dogs
This article has been cited by other articles:
|
|
 |
|
  M. K. Stickland, B. J. Morgan, and J. A. Dempsey Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans J. Physiol., March 15, 2008; 586(6): 1743 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. DeLorey, J. J. Hamann, Z. Valic, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter {alpha}-Adrenergic receptor responsiveness is preserved during prolonged exercise Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H392 - H398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Brothers, M. L. Haslund, D. W. Wray, P. B. Raven, and M. Sander Exercise-induced inhibition of angiotensin II vasoconstriction in human thigh muscle J. Physiol., December 1, 2006; 577(2): 727 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. DeLorey, J. J. Hamann, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter {alpha}-Adrenergic receptor-mediated restraint of skeletal muscle blood flow during prolonged exercise J Appl Physiol, May 1, 2006; 100(5): 1563 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. J. Hamann, and P. S. Clifford Neuropeptide Y1 receptor vasoconstriction in exercising canine skeletal muscles J Appl Physiol, December 1, 2005; 99(6): 2115 - 2120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kamper, A. J. M. de Craen, J. B. Buckwalter, J. C. Taylor, J. J. Hamann, and P. S. Clifford Role of Nitric Oxide and {alpha}-Adrenergic Receptor Responsiveness in Exercising Skeletal Muscle J Appl Physiol, April 1, 2005; 98(4): 1584 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Thomas and S. S. Segal Neural control of muscle blood flow during exercise J Appl Physiol, August 1, 2004; 97(2): 731 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Clifford and Y. Hellsten Vasodilatory mechanisms in contracting skeletal muscle J Appl Physiol, July 1, 2004; 97(1): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. C. Taylor, J. J. Hamann, and P. S. Clifford Role of nitric oxide in exercise sympatholysis J Appl Physiol, July 1, 2004; 97(1): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. J. Hamann, H. A. Kluess, and P. S. Clifford Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y? Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H144 - H149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Volianitis, C. C. Yoshiga, P. Nissen, and N. H. Secher Effect of fitness on arm vascular and metabolic responses to upper body exercise Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1736 - H1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Fadel, D. M. Keller, H. Watanabe, P. B. Raven, and G. D. Thomas Noninvasive assessment of sympathetic vasoconstriction in human and rodent skeletal muscle using near-infrared spectroscopy and Doppler ultrasound J Appl Physiol, April 1, 2004; 96(4): 1323 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. C. Taylor, J. J. Hamann, and P. S. Clifford Do P2X purinergic receptors regulate skeletal muscle blood flow during exercise? Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H633 - H639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. J. Hamann, and P. S. Clifford Vasoconstriction in active skeletal muscles: a potential role for P2X purinergic receptors? J Appl Physiol, September 1, 2003; 95(3): 953 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hamann, J. B. Buckwalter, Z. Valic, and P. S. Clifford Sympathetic restraint of muscle blood flow at the onset of dynamic exercise J Appl Physiol, June 1, 2002; 92(6): 2452 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Shiotani, H. Sato, H. Sato, H. Yokoyama, Y. Ohnishi, E. Hishida, K. Kinjo, D. Nakatani, T. Kuzuya, and M. Hori Muscle pump-dependent self-perfusion mechanism in legs in normal subjects and patients with heart failure J Appl Physiol, April 1, 2002; 92(4): 1647 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, J. S. Naik, Z. Valic, and P. S. Clifford Exercise attenuates {alpha}-adrenergic-receptor responsiveness in skeletal muscle vasculature J Appl Physiol, January 1, 2001; 90(1): 172 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Rao, H. L. Collins, and S. E. DiCarlo Postexercise alpha -adrenergic receptor hyporesponsiveness in hypertensive rats is due to nitric oxide Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R960 - R968. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
