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Am J Physiol Heart Circ Physiol 277: H380-H387, 1999;
0363-6135/99 $5.00
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Vol. 277, Issue 1, H380-H387, July 1999

Factors contributing to pressure overload-induced immediate early gene expression in adult rat hearts in vivo

Kazuhide Ogino1, Bolin Cai1, Anguo Gu1, Takushi Kohmoto2, Noriyoshi Yamamoto2, and Daniel Burkhoff1

Departments of 1 Medicine and 2 Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032

We determined the contributions of angiotensin II type 1 receptor (AT1) stimulation, adrenergic stimulation, and autonomic activation to pressure overload-induced c-fos expression in the adult rat heart in vivo. c-fos expression was increased in pressure-overloaded hearts created by aortic banding compared with sham-operated rats (458 ± 100% vs. sham, P < 0.05). GR-138950, a selective AT1 antagonist, did not blunt this expression (banding vs. banding + GR-138950: 458 ± 100% vs. 500 ± 125%, not significant). Atropine and hexamethonium partially decreased c-fos expression (banding vs. banding + atropine/hexamethonium: 700 ± 67% vs. 400 ± 67%, P < 0.05). Phentolamine had no significant effect on c-fos expression; however, propranolol inhibited the expression (banding vs. banding + propranolol: 492 ± 108% vs. 154 ± 15%, P < 0.05). The inhibition by propranolol was independent of the decreases in heart rate. Thus factors contributing to pressure overload-induced c-fos expression in adult rat hearts in vivo are different from those in neonatal myocytes in vitro undergoing stretch.

angiotensin; autonomic nervous system; signal transduction; stress


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