AJP - Heart Myographs and Tissue organ baths
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 277: H725-H731, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Segers, P.
Right arrow Articles by Verdonck, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Segers, P.
Right arrow Articles by Verdonck, P.
Vol. 277, Issue 2, H725-H731, August 1999

Pulmonary arterial compliance in dogs and pigs: the three-element windkessel model revisited

Patrick Segers1, Serge Brimioulle2, Nikos Stergiopulos3, Nico Westerhof4, Robert Naeije2, Marco Maggiorini2, and Pascal Verdonck1

1 Hydraulics Laboratory, Institute for Biomedical Technology, University of Gent, B-9000 Ghent, Belgium; 2 Laboratory for Physiology, Free University of Brussels, B-1070 Brussels, Belgium; 3 Biomedical Engineering Laboratory, École Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland; and 4 Laboratory for Physiology, Institute for Cardiovascular Research, Free University of Amsterdam, 1081 BT Amsterdam, The Netherlands

In six dogs and six weight-matched miniature pigs at baseline and after pulmonary embolization, pulmonary arterial compliance was determined using the pulse pressure method (CPPM), the three-element windkessel model (CWK-3), and the ratio of stroke volume to pulse pressure (SV/PP). CPPM was lower in pigs than in dogs at baseline (0.72 ± 0.23 vs. 1.14 ± 0.29 ml/mmHg, P < 0.05) and after embolism (0.37 ± 0.14 vs. 0.54 ± 0.16 ml/mmHg, P = 0.07) at matched flow, but not at matched flow and pressure. CPPM showed the expected inverse relation with pressure and a direct relation with flow. CWK-3 was closely correlated with CPPM, except for all dogs at baseline where CWK-3 was up to 100% higher than CPPM. Excluding these data, regression analysis yielded CWK-3 = -0.01 + 1.30 · CPPM (r2 = 0.97). CWK-3 was found to be unreliable when input impedance first harmonic modulus was close to characteristic impedance, i.e., when reflections were small. SV/PP correlated well with CPPM (SV/PP = -0.10 + 1.76 · CPPM, r2 = 0.89). We conclude that 1) CPPM is a consistent estimate of pulmonary arterial compliance in pigs and dogs, 2) CWK-3 and SV/PP overestimate compliance, and 3) CWK-3 is unreliable when wave reflections are small.

pulmonary hemodynamics; pulse pressure method; three-element windkessel; stroke volume-to-pulse pressure ratio


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-W. Lankhaar, N. Westerhof, T. J. C. Faes, K. M. J. Marques, J. T. Marcus, P. E. Postmus, and A. Vonk-Noordegraaf
Quantification of right ventricular afterload in patients with and without pulmonary hypertension
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1731 - H1737.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Muthurangu, D. Atkinson, M. Sermesant, M. E. Miquel, S. Hegde, R. Johnson, R. Andriantsimiavona, A. M. Taylor, E. Baker, R. Tulloh, et al.
Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1301 - H1306.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online