AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 277: H812-H817, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, W.
Right arrow Articles by Ma, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, W.
Right arrow Articles by Ma, R.
Vol. 277, Issue 2, H812-H817, August 1999

Cardiac sympathetic afferent sensitivity is enhanced in heart failure

Wei Wang, Harold D. Schultz, and Rong Ma

Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575

A previous study from this laboratory has shown that cardiac sympathetic afferent stimulation by epicardial application of bradykinin (BK) and capsaicin was significantly enhanced in the dog with experimental heart failure (HF). The present study determined whether activity from cardiac sympathetic chemosensitive afferent endings is enhanced in HF. Rapid ventricular pacing was induced in six dogs. Five sham dogs served as controls. At the time of the acute experiment, the dogs were anesthetized with pentobarbital sodium (30 mg/kg iv). A thoracotomy was performed in the second intercostal space, and single afferent fiber discharge from the left cardiac sympathetic nerve was recorded. Baseline cardiac sympathetic afferent discharge rate (spikes/s) and its responses to intra-atrial injection of BK were compared between sham and HF groups. Baseline cardiac sympathetic afferent discharge rate in the HF group was significantly elevated compared with the sham group (4.3 ± 0.5 vs. 2.2 ± 0.6 spikes/s, P < 0.05). In addition, cardiac sympathetic afferent responses to left intra-atrial injection of bradykinin (2 and 5 µg/kg) and capsaicin (5 and 10 µg/kg) were also significantly augmented. The sensitized cardiac sympathetic afferent responses to BK (2 and 5 µg/kg, left intra-atrial injection) in the HF group were significantly reduced by the cyclooxygenase inhibitor indomethacin (5 mg/kg iv). The sensitized cardiac sympathetic afferent response to capsaicin (5 and 10 µg/kg, left intra-atrial injection) in the HF group was preserved. It is suggested that the cardiac sympathetic chemosensitive afferent sensitivity is significantly enhanced in dogs with HF even though the baseline cardiac sympathetic afferent discharge is elevated.

cardiovascular reflex; rapid pacing; sympathetic nerves; bradykinin; capsaicin; indomethacin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. G. J. Gademan, R. J. van Bommel, C. Ypenburg, J. C. W. Haest, M. J. Schalij, E. E. van der Wall, J. J. Bax, and C. A. Swenne
Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H755 - H760.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W.-Z. Wang, L. Gao, Y.-X. Pan, I. H. Zucker, and W. Wang
AT1 receptors in the nucleus tractus solitarii mediate the interaction between the baroreflex and the cardiac sympathetic afferent reflex in anesthetized rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1137 - R1145.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
I. H. Zucker
Novel Mechanisms of Sympathetic Regulation in Chronic Heart Failure
Hypertension, December 1, 2006; 48(6): 1005 - 1011.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G.-Q. Zhu, L. Gao, K. P. Patel, I. H. Zucker, and W. Wang
ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure
J Appl Physiol, November 1, 2004; 97(5): 1746 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-Q. Zhu, L. Gao, Y. Li, K. P. Patel, I. H. Zucker, and W. Wang
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1828 - H1835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Gao, Z. Zhu, I. H. Zucker, and W. Wang
Cardiac sympathetic afferent stimulation impairs baroreflex control of renal sympathetic nerve activity in rats
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1706 - H1711.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-Q. Zhu, K. P. Patel, I. H. Zucker, and W. Wang
Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2039 - H2045.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
H. D. SCHULTZ
Cardiac Vagal Chemosensory Afferents: Function in Pathophysiological States
Ann. N.Y. Acad. Sci., June 1, 2001; 940(1): 59 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. Wang, H. D. Schultz, and R. Ma
Volume expansion potentiates cardiac sympathetic afferent reflex in dogs
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H576 - H581.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online