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1 in rat aortic endothelium
Nephrology Research and Training Center, Comprehensive Cancer Center, and Cell Adhesion and Matrix Research Center, Division of Nephrology, Department of Medicine and Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham 35294-0007; and Department of Veterans Affairs Medical Center, Birmingham, Alabama 35233
The amount of NaCl in the diet plays an
important role in modulating nitric oxide (NO) synthesis in vivo. In
the glomerulus, dietary NaCl also regulates transforming growth
factor-
1 (TGF-1) production. We hypothesized that dietary NaCl
intake regulated expression of the endothelial isoform of nitric oxide
synthase (NOS3) and TGF-1 in the aorta. Administration of 8.0% NaCl
diet to rats for 7 days did not affect blood pressure but increased steady-state mRNA and protein levels of NOS3 in the arterial wall compared with animals on 0.3% NaCl diet. Northern analysis
demonstrated increased steady-state amounts of mRNA of TGF-1 in
aortas of rats on 8.0% NaCl diet. By ELISA, both total and active
TGF-1 were increased in these vessel segments. Endothelial
denudation of aortic rings reduced active TGF-1 secretion to
undetectable levels. Addition of a neutralizing antibody to TGF- to
aortic ring segments attenuated NO production but not to that observed in animals on the 0.3% NaCl diet. The data showed that dietary NaCl
intake modulated NOS3 and TGF-1 expression in the arterial wall;
NOS3 expression was at least partially regulated by endothelial cell
production of TGF-1.
transforming growth factor-1; nitric oxide; sodium chloride; Sprague-Dawley rat
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