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Am J Physiol Heart Circ Physiol 277: H1553-H1561, 1999;
0363-6135/99 $5.00
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Vol. 277, Issue 4, H1553-H1561, October 1999

Emotional stress induces immediate-early gene expression in rat heart via activation of alpha - and beta -adrenoceptors

Takashi Ueyama1, Ken-Ichi Yoshida2, and Emiko Senba1

1 Department of Anatomy and Neurobiology, Wakayama Medical College, Wakayama 641-8509; and 2 Department of Legal Medicine, Yamaguchi University School of Medicine, Ube 755-0001, Japan

We have studied the adrenergic mechanisms of immediate-early gene (IEG) induction in the discrete types of cardiac cells with the use of in situ hybridization histochemistry in an immobilization-stress model in conscious rats. Expression of c-fos, fos B, c-jun, jun B, NGFI-A, and NGFI-B mRNA was rapidly upregulated in the endothelial, myocardial, and smooth muscle cells of coronary vessels by 15-45 min after the onset of immobilization. Simultaneous blockade of both alpha - and beta -adrenoceptors completely abolished expression of IEGs in these cardiac cells. Application of an alpha -agonist or beta -agonist alone to the perfused rat heart under constant pressure elicited the upregulation of IEGs in a fashion similar to that of emotional stress. These data suggest that activation of either alpha - or beta -adrenoceptor is sufficient to evoke expression of these genes and that there may be cross talk in signal transduction downstream from alpha - and beta -adrenoceptors in cardiac cells.

catecholamine; endothelial cells; cardiac myocytes; coronary artery; immobilization stress


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