AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 277: H1553-H1561, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ueyama, T.
Right arrow Articles by Senba, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ueyama, T.
Right arrow Articles by Senba, E.
Vol. 277, Issue 4, H1553-H1561, October 1999

Emotional stress induces immediate-early gene expression in rat heart via activation of alpha - and beta -adrenoceptors

Takashi Ueyama1, Ken-Ichi Yoshida2, and Emiko Senba1

1 Department of Anatomy and Neurobiology, Wakayama Medical College, Wakayama 641-8509; and 2 Department of Legal Medicine, Yamaguchi University School of Medicine, Ube 755-0001, Japan

We have studied the adrenergic mechanisms of immediate-early gene (IEG) induction in the discrete types of cardiac cells with the use of in situ hybridization histochemistry in an immobilization-stress model in conscious rats. Expression of c-fos, fos B, c-jun, jun B, NGFI-A, and NGFI-B mRNA was rapidly upregulated in the endothelial, myocardial, and smooth muscle cells of coronary vessels by 15-45 min after the onset of immobilization. Simultaneous blockade of both alpha - and beta -adrenoceptors completely abolished expression of IEGs in these cardiac cells. Application of an alpha -agonist or beta -agonist alone to the perfused rat heart under constant pressure elicited the upregulation of IEGs in a fashion similar to that of emotional stress. These data suggest that activation of either alpha - or beta -adrenoceptor is sufficient to evoke expression of these genes and that there may be cross talk in signal transduction downstream from alpha - and beta -adrenoceptors in cardiac cells.

catecholamine; endothelial cells; cardiac myocytes; coronary artery; immobilization stress


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
T. Kanzleiter, T. Schneider, I. Walter, F. Bolze, C. Eickhorst, G. Heldmaier, S. Klaus, and M. Klingenspor
Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis
Physiol Genomics, December 14, 2005; 24(1): 37 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Kawata, K.-i. Yoshida, A. Kawamoto, H. Kurioka, E. Takase, Y. Sasaki, K. Hatanaka, M. Kobayashi, T. Ueyama, T. Hashimoto, et al.
Ischemic Preconditioning Upregulates Vascular Endothelial Growth Factor mRNA Expression and Neovascularization via Nuclear Translocation of Protein Kinase C {epsilon} in the Rat Ischemic Myocardium
Circ. Res., April 13, 2001; 88(7): 696 - 704.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online