AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 277: H1609-H1617, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawai, H.
Right arrow Articles by Liang, C.-S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawai, H.
Right arrow Articles by Liang, C.-S.
Vol. 277, Issue 4, H1609-H1617, October 1999

ACE inhibition improves cardiac NE uptake and attenuates sympathetic nerve terminal abnormalities in heart failure

Hiroya Kawai, Tai-Hwang M. Fan, Erdan Dong, Rizwan A. Siddiqui, Akito Yatani, Suzanne Y. Stevens, and Chang-Seng Liang

Cardiology Unit, Department of Medicine, and Departments of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642

Cardiac sympathetic nerve terminal dysfunction plays an important role in the downregulation of myocardial beta -adrenoceptors in heart failure. To determine whether chronic angiotensin-converting enzyme (ACE) inhibition improved cardiac sympathetic nerve terminal function and hence increased myocardial beta -adrenergic responsiveness, we administered ACE inhibitors to dogs with chronic right-sided heart failure (RHF) produced by tricuspid avulsion and pulmonary artery constriction. The RHF animals exhibited fluid retention, elevated right heart filling pressures, blunted inotropic response to isoproterenol, and reduced beta -adrenoceptor density. These changes were accompanied by decreases in right ventricular norepinephrine (NE) uptake and neuronal NE histofluorescence and tyrosine hydroxylase immunoreactive profiles. ACE inhibitors had no effect on the production of heart failure but greatly reduced the attenuation of cardiac NE uptake, neuronal NE histofluorescence, and tyrosine hydroxylase immunoreactive profiles. ACE inhibition also improved the inotropic response to isoproterenol and restored myocardial beta -adrenoceptor density. The changes probably are caused by reduction of cardiac NE release by ACE inhibition and may contribute to the beneficial effects of ACE inhibitor therapy in patients with chronic heart failure.

congestive heart failure; sympathetic nerves; angiotensin-converting enzyme inhibition; tyrosine hydroxylase; norepinephrine


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
W. Raasch, T. Bartels, A. Gieselberg, A. Dendorfer, and P. Dominiak
Angiotensin I-Converting Enzyme Inhibition Increases Cardiac Catecholamine Content and Reduces Monoamine Oxidase Activity via an Angiotensin Type 1 Receptor-Mediated Mechanism
J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 428 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Kawai, S. Y. Stevens, and C.-S. Liang
Renin-angiotensin system inhibition on noradrenergic nerve terminal function in pacing-induced heart failure
Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H3012 - H3019.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. M. Kaye, G. Vaddadi, S. L. Gruskin, X.-J. Du, and M. D. Esler
Reduced Myocardial Nerve Growth Factor Expression in Human and Experimental Heart Failure
Circ. Res., April 14, 2000; 86 (7): e80 - e84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Qin, R. S. Vulapalli, S. Y. Stevens, and C.-S. Liang
Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF
Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H363 - H371.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online