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Am J Physiol Heart Circ Physiol 277: H1679-H1689, 1999;
0363-6135/99 $5.00
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Vol. 277, Issue 5, H1679-H1689, November 1999

Baroreflex stabilization of the double product

Bruce N. van Vliet1 and Jean-Pierre Montani2

1 Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6; and 2 Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland

We investigated whether the baroreflex control of heart rate (HR) stabilizes the product of arterial pressure (PA) and HR, called the double product (DP), an indirect indicator of left ventricular oxygen consumption. During pharmacological increases and decreases of PA in conscious rabbits, the mean (±SE) rate of change of the DP with respect to PA (dDP/dPA) was -88 ± 36 and -20 ± 36 DP units/mmHg, respectively. Regression analysis of all peak responses obtained in individual rats produced a dDP/dPA value of 15 ± 16 DP units/mmHg. These estimates were significantly less than the dDP/dPA value predicted if HR were constant (184 ± 7 DP units/mmHg) and were not significantly different from zero. We also compared values of baroreflex sensitivity (BRS) from the literature with those calculated to provide ideal stabilization of the DP. BRS values were significantly correlated with the calculated ideal values (R = 0.95; n = 14). BRS averaged 128 ± 24% of the ideal value in all species and 148 ± 28% in mammals and birds. Our results suggest that stabilization of the DP is a common consequence of the baroreflex control of heart rate.

baroreceptors; cardiac metabolism; left ventricular oxygen consumption; heart rate regulation; pressure-rate product


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B. N. Van Vliet, F. Belforti, and J.-P. Montani
Baroreflex stabilization of the double (pressure-rate) product at 0.05 Hz in conscious rabbits
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1746 - R1753.
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