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1 Arizona Prevention Center and 2 Sarver Heart Center and Department of Surgery, University of Arizona, Tucson, Arizona 85724
Our study
compared left ventricular (LV) function between senescent and young
adult mice through in situ pressure-volume loop analysis. Two groups of
mice (n = 9 each), 6-mo-old and
16-mo-old (senescent) mice, were anesthetized with urethan and
-chloralose, and their LV were instrumented with a Millar 1.4-Fr
conductance micromanometer catheter for the acquisition of the
pressure-volume loops. The senescent mice had a significantly decreased
contractile function related to load-dependent parameters, including
stroke volume index, ejection fraction, cardiac output index, stroke work index, and maximum derivative of change in systolic pressure over
time. The load-independent parameters, preload recruitable stroke work
and the slope (end-systolic volume elastance) of the end-systolic
pressure-volume relationship, were significantly decreased in the
senescent mice. Heart rate and arterial elastance were not different
between the two groups; however, the ventricular-to-vascular coupling
ratio (ratio of elastance of artery to end-systolic volume elastance)
was increased by threefold in the senescent mice
(P < 0.001). Thus there
were significant decreases in contractile function in the senescent
mouse heart that appeared to be related to reduced mechanical
efficiency but not related to arterial elastance.
senescence; conductance catheter; end-systolic pressure-volume relationship; preload recruitable stroke work
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