AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 277: H2451-H2457, 1999;
0363-6135/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dickson, E. W.
Right arrow Articles by Przyklenk, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dickson, E. W.
Right arrow Articles by Przyklenk, K.
Vol. 277, Issue 6, H2451-H2457, December 1999

SPECIAL TOPIC
Rabbit heart can be "preconditioned" via transfer of coronary effluent

Eric W. Dickson1,2, Mojca Lorbar3, William A. Porcaro1, Richard A. Fenton2, Christopher P. Reinhardt4, Anne Gysembergh5, and Karin Przyklenk5,6

Departments of 1 Emergency Medicine and 2 Physiology and 3 Division of Cardiology, University of Massachusetts Medical School, Worcester, 01655; 4 BioPAL, Inc., Wellesley Hills, Massachusetts 02481; 5 Heart Institute, Good Samaritan Hospital, and 6 Section of Cardiology, University of Southern California, Los Angeles, California 90017-2395

Brief myocardial ischemia not only evokes a local cardioprotective or "preconditioning" effect but also can render remote myocardium resistant to sustained ischemia. We propose the following hypotheses: remote protection is initiated by a humoral trigger; brief ischemia-reperfusion will result in release of the humoral trigger (possibly adenosine and/or norepinephrine) into the coronary effluent; and transfer of this effluent to a virgin acceptor heart will elicit cardioprotection. To test these concepts, effluent was collected during normal perfusion from donor-control hearts and during preconditioning ischemia-reperfusion from donor-preconditioned (PC) hearts. After reoxygenation occurred and aliquots for measurement of adenosine and norepinephrine content were harvested, effluent was transfused to acceptor-control and acceptor-PC hearts. All hearts then underwent 40 min of global ischemia and 60 min of reperfusion, and infarct size was delineated by tetrazolium staining. Mean infarct size was smaller in both donor- and acceptor-PC groups (9% of left ventricle) than in donor- and acceptor-control groups (36% and 34%; P < 0.01). Protection in acceptor-PC hearts could not, however, be attributed to adenosine or norepinephrine. Thus preconditioning-induced cardioprotection can be transferred between rabbit hearts by transfusion of coronary effluent. Although adenosine and norepinephrine are apparently not responsible, these results suggest that remote protection is initiated by a humoral mechanism.

myocardial ischemia; myocardial infarction; adenosine; norepinephrine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. W. Dickson, C. P. Hogrefe, P. S. Ludwig, L. W. Ackermann, L. L. Stoll, and G. M. Denning
Exercise enhances myocardial ischemic tolerance via an opioid receptor-dependent mechanism
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H402 - H408.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. C. Huffman, S. E. Koch, and K. L. Butler
Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H257 - H262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. B. Kristiansen, O. Henning, R. K. Kharbanda, J. E. Nielsen-Kudsk, M. R. Schmidt, A. N. Redington, T. T. Nielsen, and H. E. Botker
Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1252 - H1256.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. D. Addison, P. C. Neligan, H. Ashrafpour, A. Khan, A. Zhong, M. Moses, C. R. Forrest, and C. Y. Pang
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1435 - H1443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. W. Dickson, R. J. Tubbs, W. A. Porcaro, W. J. Lee, D. J. Blehar, R. E. Carraway, C. E. Darling, and K. Przyklenk
Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and KATP channels
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H22 - H28.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. A. Liem, P. D. Verdouw, H. Ploeg, S. Kazim, and D. J. Duncker
Sites of action of adenosine in interorgan preconditioning of the heart
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H29 - H37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. M. Chilian and G. J. Gross
Prologue: ischemic preconditioning in cardiac vascular muscle
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2416 - H2417.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online