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Department of Physiology, State University of New York Health Sciences Center at Syracuse, Syracuse, New York 13210
We tested the hypothesis that aged animals
are as responsive as the young adult animals in expanding collateral
vasculature under a similar treatment of basic fibroblast growth factor
(bFGF). Two age groups of male Fischer 344 rats (11 mo old; n = 32, 23 mo old; n = 43) weighing ~385 g were subdivided into
normal, acute ligation [femoral artery (FA) ligated 3 days before
blood flow (BF) measurement] or ligated groups for 16 days and
received recombinant human bFGF intra-arterial infusion at doses of 0, 0.5, 5, and 50 µg · kg
1 · day1.
BF was determined with 85Sr- and 141Ce-labeled
microspheres during treadmill running at 15 and 20 m/min at 15% grade.
Blood presure (BP) values were ~149 and ~163 mmHg (p < 0.05); heart rates were ~496 and ~512 beats/min in the aged and
young adult groups during running, respectively. Maximal collateral BF
values were confirmed by no additional BF increase in the calf muscle
at the higher speed. Ligation of the FA for 3 days reduced the BF
reserve to the calf muscle by ~90%. Calf muscle BF was modestly
greater (10 ml · min1 · 100 g1) by 16 days in the carrier group.
bFGF infusion expanded collateral BF in a dose-dependent manner with an
increase of 33 and 42 ml · min1 · 100 g1 (P < 0.001) in the 5 and 50 µg · kg1 · day1
bFGF groups, respectively. Aged animals showed similar BF improvements as observed with the adult groups in response to ligation surgery and
bFGF treatment. Our data indicate that the aged rats (~23 mo old)
remain responsive to exogenous bFGF induced in developing collateral-dependent BF as the young adult (~11 mo old) controls. This suggests that the influence of bFGF in expanding collateral BF
should not be preempted in the aged group, the population most affected
by peripheral arterial insufficiency.
Fischer 344 rat; collateral circulation; intermittent claudication; vascular remodeling; microspheres; basic fibroblast growth factor
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