| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Pharmacology and 2 Cardiovascular Research, Berlex Biosciences, Richmond, California 94804
Atherosclerosis develops and progresses spontaneously in apolipoprotein E-knockout (apoE-KO) mice. A direct consequence of atherosclerosis is an increase in vascular stiffness. Pulse wave velocity (PWV) has been used to assess the stiffness of large vessels and was found to be increased in patients with atherosclerosis. In the present study, aortic stiffness was assessed by PWV in 4- and 13-mo-old apoE-KO mice and age-matched controls (C57BL/6J). In 13-mo-old apoE-KO mice with extensive atherosclerotic lesions in the aorta (61 ± 4%), PWV increased significantly (3.8 ± 0.2 m/s) compared with controls (2.9 ± 0.2 m/s). Endothelial nitric oxide (EDNO)-mediated vasorelaxation in response to ACh was markedly diminished in the aortic rings isolated from 13-mo-old apoE-KO mice compared with age-matched controls. In contrast, in 4-mo-old apoE-KO mice with only moderate atherosclerotic lesions in the aorta (23 ± 5%), there were no significant changes in PWV and EDNO-mediated relaxation compared with controls. Blood pressure was not different among the four groups of mice. There were no significant differences in endothelium-independent vascular responses to sodium nitroprusside among different groups investigated. Histological evaluation revealed focal fragmentation of the elastic laminae in the aortic walls of 13-mo-old apoE-KO mice. These results demonstrate for the first time that aortic stiffness determined by PWV increases in 13-mo-old apoE-KO mice. Endothelial dysfunction and elastic destruction in vascular wall caused by atherosclerosis may have contributed.
compliance; elastin degradation; endothelium-dependent relaxation; nitric oxide
This article has been cited by other articles:
|
|
 |
|
  S. Ryoo, G. Gupta, A. Benjo, H. K. Lim, A. Camara, G. Sikka, H. K. Lim, J. Sohi, L. Santhanam, K. Soucy, et al. Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis Circ. Res., April 25, 2008; 102(8): 923 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Soucy, S. Ryoo, A. Benjo, H. K. Lim, G. Gupta, J. S. Sohi, J. Elser, M. A. Aon, D. Nyhan, A. A. Shoukas, et al. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness J Appl Physiol, December 1, 2006; 101(6): 1751 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Fitch, J. C. Rutledge, Y.-X. Wang, A. F. Powers, J.-L. Tseng, T. Clary, and G. M. Rubanyi Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1190 - H1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. White, S. Ryoo, D. Li, H. C. Champion, J. Steppan, D. Wang, D. Nyhan, A. A. Shoukas, J. M. Hare, and D. E. Berkowitz Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats Hypertension, February 1, 2006; 47(2): 245 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-X. Wang, B. Martin-McNulty, V. da Cunha, J. Vincelette, X. Lu, Q. Feng, M. Halks-Miller, M. Mahmoudi, M. Schroeder, B. Subramanyam, et al. Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice by Inhibiting Apoptosis and Proteolysis Circulation, May 3, 2005; 111(17): 2219 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Hartley, A. K. Reddy, S. Madala, M. L. Entman, L. H. Michael, and G. E. Taffet Noninvasive ultrasonic measurement of arterial wall motion in mice Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1426 - H1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Reddy, Y.-H. Li, T. T. Pham, L. N. Ochoa, M. T. Trevino, C. J. Hartley, L. H. Michael, M. L. Entman, and G. E. Taffet Measurement of aortic input impedance in mice: effects of age on aortic stiffness Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1464 - H1470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Martin-McNulty, D. M. Tham, V. da Cunha, J. J. Ho, D. W. Wilson, J. C. Rutledge, G. G. Deng, R. Vergona, M. E. Sullivan, and Y.-X. Wang 17{beta}-Estradiol Attenuates Development of Angiotensin II-Induced Aortic Abdominal Aneurysm in Apolipoprotein E-Deficient Mice Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1627 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gervais, S. Pons, A. Nicoletti, C. Cosson, J.-F. Giudicelli, and C. Richer Fluvastatin Prevents Renal Dysfunction and Vascular NO Deficit in Apolipoprotein E-Deficient Mice Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 183 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Tham, B. Martin-McNulty, Y.-X. Wang, V. Da Cunha, D. W. Wilson, C. N. Athanassious, A. F. Powers, M. E. Sullivan, and J. C. Rutledge Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1442 - R1449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Imai, T. Shindo, K. Maemura, M. Sata, Y. Saito, Y. Kurihara, M. Akishita, J. Osuga, S. Ishibashi, K. Tobe, et al. Resistance to Neointimal Hyperplasia and Fatty Streak Formation in Mice With Adrenomedullin Overexpression Arterioscler. Thromb. Vasc. Biol., August 1, 2002; 22(8): 1310 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tatchum-Talom, C. Martel, and A. Marette Influence of estrogen on aortic stiffness and endothelial function in female rats Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H491 - H498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gros, R. Van Wert, X. You, E. Thorin, and M. Husain Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H380 - H388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-X. Wang, B. Martin-McNulty, A. D. Freay, D. A. Sukovich, M. Halks-Miller, W.-W. Li, R. Vergona, M. E. Sullivan, J. Morser, W. P. Dole, et al. Angiotensin II Increases Urokinase-Type Plasminogen Activator Expression and Induces Aneurysm in the Abdominal Aorta of Apolipoprotein E-Deficient Mice Am. J. Pathol., October 1, 2001; 159(4): 1455 - 1464. [Abstract] [Full Text]
|
|
|
|
|
|
E. Lutgens, E. D. de Muinck, S. Heeneman, and M. J.A.P. Daemen Compensatory Enlargement and Stenosis Develop in ApoE-/- and ApoE*3-Leiden Transgenic Mice Arterioscler. Thromb. Vasc. Biol., August 1, 2001; 21(8): 1359 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Fitch, R. Vergona, M. E. Sullivan, and Y.-X. Wang Nitric oxide synthase inhibition increases aortic stiffness measured by pulse wave velocity in rats Cardiovasc Res, August 1, 2001; 51(2): 351 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Hartley, A. K. Reddy, S. Madala, B. Martin-McNulty, R. Vergona, M. E. Sullivan, M. Halks-Miller, G. E. Taffet, L. H. Michael, M. L. Entman, et al. Hemodynamic changes in apolipoprotein E-knockout mice Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2326 - H2334. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
