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Am J Physiol Heart Circ Physiol 278: H484-H492, 2000;
0363-6135/00 $5.00
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Vol. 278, Issue 2, H484-H492, February 2000

Developmental differences in delayed rectifying outward current in feline ventricular myocytes

Héctor Barajas-Martínez, Alejandro Elizalde, and José A. Sánchez-Chapula

Unidad de Investigación Carlos Méndez, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, C.P. 28040, Colima, Mexico

In the present work, we found that the delayed rectifying outward potassium current (IK) in adult and neonatal cat ventricular myocytes consists of both rapid and slow components, IKr and IKs, respectively, which can be isolated pharmacologically. Thus after complete blockade of IKr with dofetilide, the remaining IKs current is homogeneous, as shown by an envelope of tails test. IKr maximum tail current density, measured at -40 mV, was similar in adult and neonatal myocytes. IKs maximum tail current density in neonatal myocytes, measured at -40 mV, was significantly smaller than in adult myocytes. Activation kinetics of IKr and IKs was similar in both age groups. However, the IKr deactivation time course was significantly faster in neonatal than in adult myocytes. Developmental differences in the subunit composition of IKr that display distinctly different deactivation kinetics are suggested.

cat; rapid delayed rectifying current; slow delayed rectifying current; dofetilide


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