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Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
Vasodilator responses were assessed in resistance
arteries (100-200 µm) isolated from the gracilis muscle of
normotensive rats after changes in dietary salt intake. Sprague-Dawley
rats were maintained on either a high-salt (HS) diet (4.0% NaCl) or a
low-salt (LS) diet (0.4% NaCl) for 4-8 wk (chronic) or 3 days (short-term) with water ad libitum. One group of short-term HS rats
received a continuous intravenous infusion of a low dose (5 ng · kg
1 · min1)
of ANG II to prevent the ANG II suppression that occurs with HS
diet. Short-term and chronic HS diet eliminated arterial
dilation in response to ACh and reduced
PO2 (30-40 mmHg) and the stable
prostacyclin analog iloprost. ANG II infusion preserved the response to
these vasodilator stimuli in short-term HS animals. Dilator responses to sodium nitroprusside and forskolin were unaffected by HS diet. These findings suggest that ANG II suppression during HS
diet impairs vascular relaxation mechanisms upstream from the cAMP and
cGMP second messenger systems.
angiotensin II; sodium; vascular smooth muscle; microcirculation; vascular relaxation
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