AJP - Heart AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 278: H595-H603, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, P.
Right arrow Articles by Schwartz, G. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, P.
Right arrow Articles by Schwartz, G. G.
Vol. 278, Issue 2, H595-H603, February 2000

Glucose-insulin-potassium preserves systolic and diastolic function in ischemia and reperfusion in pigs

Peili Zhu1, Li Lu2, Ya Xu2, Clifford Greyson2, and Gregory G. Schwartz2

2 Cardiology Section, Department of Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80220; and 1 Cardiovascular Research Institute, University of California, San Francisco, California 94121

Clinical and experimental studies have suggested benefit of treatment with intravenous glucose-insulin-potassium (GIK) in acute myocardial infarction. However, patients hospitalized with acute coronary syndromes often experience recurrent myocardial ischemia without infarction that may cause progressive left ventricular (LV) dysfunction. This study tested the hypothesis that anticipatory treatment with GIK attenuates both systolic and diastolic LV dysfunction resulting from ischemia and reperfusion without infarction in vivo. Open-chest, anesthetized pigs underwent 90 min of moderate regional ischemia (mean subendocardial blood flow 0.3 ml · g-1 · min-1) and 90 min reperfusion. Eight pigs were treated with GIK (300 g/l glucose, 50 U/l insulin, and 80 meq/l KCl; infused at 2 ml · kg-1 · h-1) beginning 30 min before ischemia and continuing through reperfusion. Eight untreated pigs comprised the control group. Regional LV wall area was measured with orthogonal pairs of sonomicrometry crystals. GIK significantly increased myocardial glucose uptake and lactate release during ischemia. After reperfusion, indexes of regional systolic function (external work and fractional systolic wall area reduction), regional diastolic function (maximum rate of diastolic wall area expansion), and global LV function (LV positive and negative maximum rate of change in pressure with respect to time) recovered to a significantly greater extent in GIK-treated pigs than in control pigs (all P < 0.05). The findings suggest that the clinical utility of GIK may extend beyond treatment of acute myocardial infarction to anticipatory metabolic protection of myocardium in patients at risk for recurrent episodes of ischemia.

ventricular function; energy metabolism; substrates


This article has been cited by other articles:


Home page
 CirculationHome page
R. A. Kloner and R. W. Nesto
Glucose-Insulin-Potassium for Acute Myocardial Infarction: Continuing Controversy Over Cardioprotection
Circulation, May 13, 2008; 117(19): 2523 - 2533.
[Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
J. W. A. Smit and J. A. Romijn
Acute insulin resistance in myocardial ischemia: causes and consequences.
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2006; 10(3): 215 - 219.
[Abstract] [PDF]

Home page
 Canadian J. AnesthesiaHome page
G. Carvalho, A. Moore, T. Al-Backer, K. Lachapelle, and T. Schricker
26481 - CARDIOPROTECTIVE EFFECT OF INSULIN AND MAINTENANCE OF NORMOGLYCEMIA
Can J Anesth, June 1, 2006; 53(suppl_1): 26481 - 26481.
[Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
D. W. Quinn, D. Pagano, and R. S. Bonser
Glucose and Insulin Influences on Heart and Brain in Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2005; 9(2): 173 - 178.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
M. Galinanes and A. G Fowler
Role of clinical pathologies in myocardial injury following ischaemia and reperfusion
Cardiovasc Res, February 15, 2004; 61(3): 512 - 521.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. Clement, S. S. Braithwaite, M. F. Magee, A. Ahmann, E. P. Smith, R. G. Schafer, and I. B. Hirsch
Management of Diabetes and Hyperglycemia in Hospitals
Diabetes Care, February 1, 2004; 27(2): 553 - 591.
[Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
C.J. Zuurbier
Postischemic Myocardial Metabolism
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 59 - 65.
[PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Ramanathan, K. Shirota, S. Morita, T. Nishimura, Y. Huang, and S. N. Hunyor
Glucose-insulin-potassium solution improves left ventricular mechanics in diabetes
Ann. Thorac. Surg., February 1, 2002; 73(2): 582 - 587.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. Gao, E. Gao, T.-L. Yue, E. H. Ohlstein, B. L. Lopez, T. A. Christopher, and X.-L. Ma
Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion: The Roles of PI3-Kinase, Akt, and Endothelial Nitric Oxide Synthase Phosphorylation
Circulation, March 26, 2002; 105(12): 1497 - 1502.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online