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Am J Physiol Heart Circ Physiol 278: H633-H642, 2000;
0363-6135/00 $5.00
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Vol. 278, Issue 2, H633-H642, February 2000

Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats

Fumiki Yoshihara1, Toshio Nishikimi1, Takeshi Horio2, Chikao Yutani3, Noritoshi Nagaya1, Hisayuki Matsuo1, Tohru Ohe4, and Kenji Kangawa1

1 Research Institute, 2 Division of Hypertension, and 3 Division of Pathology, National Cardiovascular Center, Suita, Osaka 565-8565; and 4 Department of Cardiovascular Medicine, Okayama University Medical School, Okayama 700-8558, Japan

This study was designed to investigate the pathophysiological significance of adrenomedullin (AM) concentration in volume- and pressure-overloaded cardiac hypertrophy. We measured ventricular AM concentrations and compared them with changes of alpha -actin and myosin heavy chain (MHC) mRNA isoforms after the creation of an aortocaval (AC) shunt as a volume-overload model or the injection of monocrotaline (MCT) as a pressure-overload model, respectively. The left ventricular AM levels after the creation of AC shunt and the right ventricular AM levels after the injection of MCT were significantly increased and correlated with changes of the alpha -actin and MHC mRNA isoforms. However, the ventricular AM mRNA expressions were increased and correlated with ventricular AM concentrations only in the AC shunt model. These results suggest that the ventricular AM levels are upregulated in both the volume- and pressure-overloaded cardiac hypertrophy by differential transcriptional regulation and that the ventricular AM may be a biochemical marker for the volume and pressure overload to the ventricle.

hypertrophy; ribonucleic acid; alpha -actin; myosin heavy chain


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