| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Restoration of Appearance and Function Trust, Institute of Plastic Surgery, Mount Vernon Hospital, Northwood HA6 2RN; 2 Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, United Kingdom
Bilirubin is a potent antioxidant generated intracellularly during the degradation of heme by the enzyme heme oxygenase. The purpose of this study was to determine the role of increased cardiac bilirubin in protection against postischemic myocardial dysfunction. Rat hearts were isolated and perfused according to the Langendorff technique to evaluate the recovery of myocardial function after 30 min of global ischemia and 60 min of reperfusion. We found that upregulation of the inducible isoform of heme oxygenase (HO-1) by treatment of animals with hemin 24 h before ischemia ameliorated myocardial function and reduced infarct size (tetrazolium staining) on reperfusion of isolated hearts. Tin protoporphyrin IX, an inhibitor of heme oxygenase activity, completely abolished the improved postischemic myocardial performance observed after hemin-mediated HO-1 induction. Likewise, cardiac tissue injury was exacerbated by treatment with tin protoporphyrin IX. Increased cardiac HO-1 expression and heme oxygenase activity were associated with enhanced tissue bilirubin content and an increased rate of bilirubin release into the perfusion buffer. Furthermore, exogenously administered bilirubin at concentrations as low as 100 nanomolar significantly restored myocardial function and minimized both infarct size and mitochondrial damage on reperfusion. Our data provide strong evidence for a primary role of HO-1-derived bilirubin in cardioprotection against reperfusion injury.
antioxidant genes; heat shock proteins; preconditioning; infarct size; carbon monoxide
This article has been cited by other articles:
|
|
 |
|
  C. Angeloni, E. Leoncini, M. Malaguti, S. Angelini, P. Hrelia, and S. Hrelia Role of quercetin in modulating rat cardiomyocyte gene expression profile Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1233 - H1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Kinobe, Y. Ji, J. Z. Vlahakis, R. Motterlini, J. F. Brien, W. A. Szarek, and K. Nakatsu Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 763 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L'Abbate, D. Neglia, C. Vecoli, M. Novelli, V. Ottaviano, S. Baldi, R. Barsacchi, A. Paolicchi, P. Masiello, G. S. Drummond, et al. Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3532 - H3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Natarajan, F. N. Salloum, B. J. Fisher, E. D. Ownby, R. C. Kukreja, and A. A. Fowler 3rd Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1571 - H1580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, J. A. Simpson, K. R. Brunt, C. A. Ward, S. R. R. Hall, R. T. Kinobe, V. Barrette, M. Y. Tse, S. C. Pang, A. S. Pachori, et al. Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H48 - H59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kirkby, C. Baylis, A. Agarwal, B. Croker, L. Archer, and C. Adin Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo Am J Physiol Renal Physiol, February 1, 2007; 292(2): F888 - F894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Abraham and G. Drummond CD163-Mediated Hemoglobin-Heme Uptake Activates Macrophage HO-1, Providing an Antiinflammatory Function Circ. Res., October 27, 2006; 99(9): 911 - 914. [Full Text] [PDF]
|
|
|
|
|
|
M. G. Bani-Hani, D. Greenstein, B. E. Mann, C. J. Green, and R. Motterlini Modulation of Thrombin-Induced Neuroinflammation in BV-2 Microglia by Carbon Monoxide-Releasing Molecule 3 J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1315 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Pryor, K. N. Houk, C. S. Foote, J. M. Fukuto, L. J. Ignarro, G. L. Squadrito, and K. J. A. Davies Free radical biology and medicine: it's a gas, man! Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R491 - R511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bak, I. Lekli, B. Juhasz, N. Nagy, E. Varga, J. Varadi, R. Gesztelyi, G. Szabo, L. Szendrei, I. Bacskay, et al. Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1329 - H1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Converso, C. Taille, M. C. Carreras, A. Jaitovich, J. J. Poderoso, and J. Boczkowski HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism FASEB J, June 1, 2006; 20(8): 1236 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tayem, T. R. Johnson, B. E. Mann, C. J. Green, and R. Motterlini Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule Am J Physiol Renal Physiol, April 1, 2006; 290(4): F789 - F794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Kirkby and C. A. Adin Products of heme oxygenase and their potential therapeutic applications Am J Physiol Renal Physiol, March 1, 2006; 290(3): F563 - F571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Pachori, L. G. Melo, L. Zhang, S. D. Solomon, and V. J. Dzau Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery J. Am. Coll. Cardiol., February 7, 2006; 47(3): 635 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kamada, F. S. Gaskin, T. Yamaguchi, P. Carter, T. Yoshikawa, M. Yusof, and R. J. Korthuis Role of calcitonin gene-related peptide in the postischemic anti-inflammatory effects of antecedent ethanol ingestion Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H531 - H537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Neto, A. Nakao, H. Toyokawa, M. A. Nalesnik, A. J. Romanosky, K. Kimizuka, T. Kaizu, N. Hashimoto, O. Azhipa, D. B. Stolz, et al. Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy Am J Physiol Renal Physiol, February 1, 2006; 290(2): F324 - F334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Sarady-Andrews, F. Liu, D. Gallo, A. Nakao, M. Overhaus, R. Ollinger, A. M. Choi, and L. E. Otterbein Biliverdin administration protects against endotoxin-induced acute lung injury in rats Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1131 - L1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guo, A. B. Stein, W.-J. Wu, X. Zhu, W. Tan, Q. Li, and R. Bolli Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and {delta}1-opioid receptor agonists is mediated by iNOS Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2251 - H2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dawn and R. Bolli HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H522 - H524. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vera, J. R. Henegar, H. A. Drummond, J. M. Rimoldi, and D. E. Stec Protective Effect of Carbon Monoxide-Releasing Compounds in Ischemia-Induced Acute Renal Failure J. Am. Soc. Nephrol., April 1, 2005; 16(4): 950 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Adin, B. P. Croker, and A. Agarwal Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney Am J Physiol Renal Physiol, April 1, 2005; 288(4): F778 - F784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pflueger, A. J. Croatt, T. E. Peterson, L. A. Smith, L. V. d'Uscio, Z. S. Katusic, and K. A. Nath The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II Am J Physiol Renal Physiol, March 1, 2005; 288(3): F552 - F558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Foresti, M. Hoque, D. Monti, C. J. Green, and R. Motterlini Differential Activation of Heme Oxygenase-1 by Chalcones and Rosolic Acid in Endothelial Cells J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 686 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-m. Liu, K. J. Peyton, D. Ensenat, H. Wang, A. I. Schafer, J. Alam, and W. Durante Endoplasmic Reticulum Stress Stimulates Heme Oxygenase-1 Gene Expression in Vascular Smooth Muscle: ROLE IN CELL SURVIVAL J. Biol. Chem., January 14, 2005; 280(2): 872 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Demougeot, M. Van Hoecke, N. Bertrand, A. Prigent-Tessier, C. Mossiat, A. Beley, and C. Marie Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2'-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1080 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Hu, Y.-H. Chen, M.-T. Chiang, and L.-Y. Chau Heme Oxygenase-1 Inhibits Angiotensin II-Induced Cardiac Hypertrophy In Vitro and In Vivo Circulation, July 20, 2004; 110(3): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishikawa, D. W. Stepp, D. Merkus, D. Jones, and W. M. Chilian In vivo role of heme oxygenase in ischemic coronary vasodilation Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2296 - H2304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Sedlak and S. H. Snyder Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle Pediatrics, June 1, 2004; 113(6): 1776 - 1782. [Full Text] [PDF]
|
|
|
|
|
|
E. M. Sikorski, T. Hock, N. Hill-Kapturczak, and A. Agarwal The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury Am J Physiol Renal Physiol, March 1, 2004; 286(3): F425 - F441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Clark, P. Naughton, S. Shurey, C. J. Green, T. R. Johnson, B. E. Mann, R. Foresti, and R. Motterlini Cardioprotective Actions by a Water-Soluble Carbon Monoxide-Releasing Molecule Circ. Res., July 25, 2003; 93 (2): e2 - e8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Chen, S.-F. Yet, and M. A. Perrella Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function Experimental Biology and Medicine, May 1, 2003; 228(5): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhuang, S. Pin, X. Li, and S. Dore Regulation of Heme Oxygenase Expression by Cyclopentenone Prostaglandins Experimental Biology and Medicine, May 1, 2003; 228(5): 499 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bhaskaran, K. Reddy, N. Radhakrishanan, N. Franki, G. Ding, and P. C. Singhal Angiotensin II induces apoptosis in renal proximal tubular cells Am J Physiol Renal Physiol, May 1, 2003; 284(5): F955 - F965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Blydt-Hansen, M. Katori, C. Lassman, B. Ke, A. J. Coito, S. Iyer, R. Buelow, R. Ettenger, R. W. Busuttil, and J. W. Kupiec-Weglinski Gene Transfer-Induced Local Heme Oxygenase-1 Overexpression Protects Rat Kidney Transplants From Ischemia/Reperfusion Injury J. Am. Soc. Nephrol., March 1, 2003; 14(3): 745 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Samb, C. Taille, A. Almolki, J. Megret, J. M. Staddon, M. Aubier, and J. Boczkowski Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L596 - L603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Durante Carbon monoxide and bile pigments: surprising mediators of vascular function Vascular Medicine, August 1, 2002; 7(3): 195 - 202. [Abstract] [PDF]
|
|
|
|
|
|
S. R. Vulapalli, Z. Chen, B. H. L. Chua, T. Wang, and C.-S. Liang Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H688 - H694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Motterlini, J. E. Clark, R. Foresti, P. Sarathchandra, B. E. Mann, and C. J. Green Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities Circ. Res., February 8, 2002; 90 (2): e17 - e24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Foresti, H. Goatly, C. J. Green, and R. Motterlini Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1976 - H1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hill-Kapturczak, V. Thamilselvan, F. Liu, H. S. Nick, and A. Agarwal Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells Am J Physiol Renal Physiol, November 1, 2001; 281(5): F851 - F859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M.K. Choi Heme Oxygenase-1 Protects the Heart Circ. Res., July 20, 2001; 89(2): 105 - 107. [Full Text] [PDF]
|
|
|
|
|
|
L. E. Otterbein and A. M. K. Choi Heme oxygenase: colors of defense against cellular stress Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1029 - L1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Motterlini, J. E. Clark, R. Foresti, P. Sarathchandra, B. E. Mann, and C. J. Green Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities Circ. Res., February 8, 2002; 90 (2): e17 - e24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-F. Yet, R. Tian, M. D. Layne, Z. Y. Wang, K. Maemura, M. Solovyeva, B. Ith, L. G. Melo, L. Zhang, J. S. Ingwall, et al. Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice Circ. Res., July 20, 2001; 89(2): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
