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Am J Physiol Heart Circ Physiol 278: H714-H722, 2000;
0363-6135/00 $5.00
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Vol. 278, Issue 3, H714-H722, March 2000

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats

Rui Wang1, Yuejin Wu2, Guanghua Tang1, Lingyun Wu2, and Salma Toma Hanna1

1 Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5; and 2 Department of Physiology, Université de Montréal, Montréal, Québec, Canada H3C 3J7

Vascular complications of diabetes are associated with abnormal Ca2+ handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltage-dependent Ca2+ channel (VDCC) currents may play an important role. In the present study, the characteristics of L-type VDCC currents in tail artery SMCs from streptozotocin-induced diabetic rats were examined. The densities, but not the voltage dependence, of L-type VDCC currents were reduced as diabetes progressed from 1 wk to 3 mo. The inhibitory effect of dibutyryl-cAMP on L-type VDCC currents was greater in diabetic SMCs than in age-matched control cells (P < 0.01). Both the stimulatory effect of BAY K 8644 and the inhibitory effect of nifedipine on L-type VDCC currents were significantly enhanced in diabetic cells. The diabetes-related abnormalities in L-type VDCC currents were mimicked by culturing SMCs with a high concentration of glucose. Our results suggest that the properties of L-type VDCC in diabetic vascular SMCs were significantly altered, partially related to the increased L-type VDCC sensitivity to cAMP and hyperglycemia.

dihydropyridines; patch-clamp; hyperglycemia; calcium channels; artery


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