| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,1 Department of Physiology, Wayne State University School of Medicine, Detroit; and 2 Department of Medicine, John D. Dingell Veterans Administration Medical Center, Detroit, Michigan 48201
We hypothesized that excessive sympathoactivation observed during strenuous exercise in subjects with heart failure (HF) may result from tonic activation of the muscle metaboreflex (MMR) via hypoperfusion of active skeletal muscle. We studied MMR responses in dogs during treadmill exercise by graded reduction of terminal aortic blood flow (TAQ) before and after induction of HF by rapid ventricular pacing. At a low workload, in both control and HF experiments, large decreases in TAQ were required to elicit the MMR pressor response. During control experiments, this pressor response resulted from increased cardiac output (CO), whereas in HF CO did not increase; thus the pressor response was solely due to peripheral vasoconstriction. In HF, MMR activation also induced higher plasma levels of vasopressin, norepinephrine (NE), and renin. At a higher workload, in control experiments any reduction of TAQ elicited MMR pressor responses. In HF, before any vascular occlusion, TAQ was already below MMR control threshold levels and reductions in TAQ again did not result in higher CO; thus SAP increased via peripheral vasoconstriction. NE rose markedly, indicating intense sympathetic activation. We conclude that in HF, the MMR is likely tonically active at moderate workloads and contributes to the tonic sympathoactivation.
dynamic exercise; hormones; dogs; Frank-Starling; rapid ventricular pacing
Deceased 15 July 1999.
This article has been cited by other articles:
|
|
 |
|
  A. Crisafulli, R. Milia, A. Lobina, M. Caddeo, F. Tocco, A. Concu, and F. Melis Haemodynamic effect of metaboreflex activation in men after running above and below the velocity of the anaerobic threshold Exp Physiol, April 1, 2008; 93(4): 447 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Sala-Mercado, M. Ichinose, R. L. Hammond, M. Coutsos, T. Ichinose, M. Pallante, F. Iellamo, and D. S. O'Leary Spontaneous baroreflex control of heart rate versus cardiac output: altered coupling in heart failure Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1304 - H1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, J. A. Sala-Mercado, D. S. O'Leary, R. L. Hammond, M. Coutsos, T. Ichinose, M. Pallante, and F. Iellamo Spontaneous baroreflex control of cardiac output during dynamic exercise, muscle metaboreflex activation, and heart failure Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1310 - H1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Iellamo, J. A. Sala-Mercado, M. Ichinose, R. L. Hammond, M. Pallante, T. Ichinose, L. W. Stephenson, and D. S. O'Leary Spontaneous baroreflex control of heart rate during exercise and muscle metaboreflex activation in heart failure Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1929 - H1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Stewart, I. Taneja, and M. S. Medow Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1908 - H1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Sala-Mercado, M. Ichinose, R. L. Hammond, T. Ichinose, M. Pallante, L. W. Stephenson, D. S. O'Leary, and F. Iellamo Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2867 - H2873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Crisafulli, E. Salis, F. Tocco, F. Melis, R. Milia, G. Pittau, M. A. Caria, R. Solinas, L. Meloni, P. Pagliaro, et al. Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2988 - H2996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Sala-Mercado, R. L. Hammond, J.-K. Kim, P. J. McDonald, L. W. Stephenson, and D. S. O'Leary Heart failure attenuates muscle metaboreflex control of ventricular contractility during dynamic exercise Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2159 - H2166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Notarius and J. S. Floras Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure J Appl Physiol, February 1, 2007; 102(2): 824 - 824. [Full Text] [PDF]
|
|
|
|
|
|
M. F. Piepoli and A. J. S. Coats COUNTERPOINT: INCREASED METABORECEPTOR STIMULATION EXPLAINS THE EXAGGERATED EXERCISE PRESSOR REFLEX SEEN IN HEART FAILURE J Appl Physiol, January 1, 2007; 102(1): 494 - 496. [Full Text] [PDF]
|
|
|
|
|
|
I. H. Zucker, H. D. Schultz, W. Wang, M. Guazzi, A. C. Scott, C. E. Negrao, M. U. P. B. Rondon, E. S. Prakash, A. L. Clark, A. Crisafulli, et al. Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure J Appl Physiol, January 1, 2007; 102(1): 498 - 501. [Full Text] [PDF]
|
|
|
|
|
|
REBUTTAL FROM DRS. PIEPOLI AND COATS J Appl Physiol, January 1, 2007; 102(1): 496a - 497. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Stewart, L. D. Montgomery, J. L. Glover, and M. S. Medow Changes in regional blood volume and blood flow during static handgrip Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H215 - H223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Miller, C. A. Smith, S. J. Hemauer, and J. A. Dempsey The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H580 - H592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Joyner Go with the flow: sympathetic control of blood flow during recovery from heart failure J Appl Physiol, July 1, 2006; 101(1): 3 - 4. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Augustyniak, E. J. Ansorge, J.-K. Kim, J. A. Sala-Mercado, R. L. Hammond, N. F. Rossi, and D. S. O'Leary Cardiovascular responses to exercise and muscle metaboreflex activation during the recovery from pacing-induced heart failure J Appl Physiol, July 1, 2006; 101(1): 14 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Sala-Mercado, R. L. Hammond, J.-K. Kim, N. F. Rossi, L. W. Stephenson, and D. S. O'Leary Muscle metaboreflex control of ventricular contractility during dynamic exercise Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H751 - H757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. O'Leary and M. J. Joyner Point: The muscle metaboreflex does restore blood flow to contracting muscles J Appl Physiol, January 1, 2006; 100(1): 357 - 361. [Full Text] [PDF]
|
|
|
|
|
|
D. S O'Leary Altered reflex cardiovascular control during exercise in heart failure: animal studies Exp Physiol, January 1, 2006; 91(1): 73 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A Smith, J. H Mitchell, and M. G Garry The mammalian exercise pressor reflex in health and disease Exp Physiol, January 1, 2006; 91(1): 89 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koba, T. Yoshida, and N. Hayashi Renal sympathetic and circulatory responses to activation of the exercise pressor reflex in rats Exp Physiol, January 1, 2006; 91(1): 111 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Kim, J. A. Sala-Mercado, R. L. Hammond, J. Rodriguez, T. J. Scislo, and D. S. O'Leary Attenuated arterial baroreflex buffering of muscle metaboreflex in heart failure Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2416 - H2423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Kim, J. A. Sala-Mercado, J. Rodriguez, T. J. Scislo, and D. S. O'Leary Arterial baroreflex alters strength and mechanisms of muscle metaboreflex during dynamic exercise Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1374 - H1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Ansorge, R. A. Augustyniak, M. L. Perinot, R. L. Hammond, J.-K. Kim, J. A. Sala-Mercado, J. Rodriguez, N. F. Rossi, and D. S. O'Leary Altered muscle metaboreflex control of coronary blood flow and ventricular function in heart failure Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1381 - H1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. O'Leary, J. A. Sala-Mercado, R. A. Augustyniak, R. L. Hammond, N. F. Rossi, and E. J. Ansorge Impaired muscle metaboreflex-induced increases in ventricular function in heart failure Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2612 - H2618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Kim, R. A. Augustyniak, J. A. Sala-Mercado, R. L. Hammond, E. J. Ansorge, N. F. Rossi, and D. S. O'Leary Heart failure alters the strength and mechanisms of arterial baroreflex pressor responses during dynamic exercise Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1682 - H1688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Ansorge, S. H. Shah, R. A. Augustyniak, N. F. Rossi, H. L. Collins, and D. S. O'Leary Muscle metaboreflex control of coronary blood flow Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H526 - H532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Miller, K. C. Beck, M. J. Joyner, A. G. Brice, and B. D. Johnson Cardiorespiratory effects of inelastic chest wall restriction J Appl Physiol, June 1, 2002; 92(6): 2419 - 2428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Notarius, D. J. Atchison, G. A. Rongen, and J. S. Floras Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1312 - H1318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Augustyniak, H. L. Collins, E. J. Ansorge, N. F. Rossi, and D. S. O'Leary Severe exercise alters the strength and mechanisms of the muscle metaboreflex Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1645 - H1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Notarius, D. J. Atchison, and J. S. Floras Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H969 - H976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hammond, R. A. Augustyniak, N. F. Rossi, K. Lapanowski, J. C. Dunbar, and D. S. O'Leary Alteration of humoral and peripheral vascular responses during graded exercise in heart failure J Appl Physiol, January 1, 2001; 90(1): 55 - 61. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
