AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 278: H1134-H1141, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Igawa, A.
Right arrow Articles by Inoue, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Igawa, A.
Right arrow Articles by Inoue, H.
Vol. 278, Issue 4, H1134-H1141, April 2000

Heterogeneous cardiac sympathetic innervation in heart failure after myocardial infarction of rats

Akihiko Igawa1, Takashi Nozawa1, Naohiro Yoshida1, Nozomu Fujii1, Minoru Inoue2, Shusaku Tazawa2, Hidetsugu Asanoi1, and Hiroshi Inoue1

1 The 2nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, and 2 Research Laboratories, Daiichi Radioisotope Laboratories, Chiba 289-1592, Japan

We examined cardiac neuronal function and beta -receptor with a dual-tracer method of [131I]meta-iodobenzylguanidine (MIBG) and [125I]iodocyanopindolol (ICYP) in rat heart failure after myocardial infarction (MI). In rats with MI, left ventricular (LV) systolic function decreased, and LV dimension and right ventricular (RV) mass increased gradually. MIBG accumulations of the noninfarcted LV (remote region) and RV decreased by 15% at 1 wk compared with sham-operated rats, and these accumulations were restored by 71% and 56%, respectively, at 24 wk compared with age-matched sham rats despite sustained depletion of myocardial norepinephrine contents in these regions. ICYP accumulation of the remote region and of the RV did not decrease at any stages. Myocardial MIBG distribution was heterogeneous at 1 wk when it was lower in the peri-infarcted region than in the remote region, associated with reduced ICYP accumulation in the peri-infarcted region. The heterogeneous distribution of both isotopes disappeared at 12 wk. Thus cardiac sympathetic neuronal alteration was coupled with downregulation of beta -receptors in rat heart failure after MI. The abnormal adrenergic signaling occurred heterogeneously in terms of ventricular distribution and time course after MI.

autonomic nervous system; beta -receptors; radioisotopes; dual-tracer method


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Fujii, T. Nozawa, A. Igawa, B.-i. Kato, N. Igarashi, M. Nonomura, H. Asanoi, S. Tazawa, M. Inoue, and H. Inoue
Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H760 - H766.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Tsuda, E. Gao, L. Evangelisti, D. Markova, X. Ma, and M.-L. Chu
Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes
Cardiovasc Res, October 1, 2003; 59(4): 926 - 933.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online