AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 278: H1142-H1152, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Osterloh, K.
Right arrow Articles by Pries, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Osterloh, K.
Right arrow Articles by Pries, A. R.
Vol. 278, Issue 4, H1142-H1152, April 2000

Determination of microvascular flow pattern formation in vivo

Kurt Osterloh, Peter Gaehtgens, and Axel R. Pries

Department of Physiology, Freie Universität Berlin, D-14195 Berlin, Germany

Blood flow in microvessels differs significantly from that of red blood cells (RBC) flowing through long, straight glass tubes in vitro. The in vivo situation is characterized by the presence of plasma favoring aggregation, by the irregular geometry of vessel segments, and by frequent branching points. Here, a method is presented to characterize flow patterns in microvascular blood flow during intravital microscopy based on Fourier analysis of recorded light intensity patterns. The interpretation of the resulting power spectra in terms of pattern size distribution was validated by model experiments employing artificial textures and by reverse transformation of idealized spectra. The determined size of RBC flow patterns in microvessels ranged from ~8 µm in capillaries to ~14 µm in vessels of >30 µm. With increasing shear rate above ~100 s-1 pattern size increased, possibly reflecting formation of short-lived flow clusters. Below ~100 s-1 an increase of pattern size with decreasing shear rate was found in experiments using local occlusion and treatment with high-molecular-weight dextran, suggesting the formation of aggregates. The dynamic process of generation and destruction of RBC flow patterns could well contribute to flow resistance in vivo in peripheral vascular beds.

Fourier analysis; aggregation; hemodynamics; shear rate


This article has been cited by other articles:


Home page
 Eur Heart JHome page
H. A.J. Struijker-Boudier, A. E. Rosei, P. Bruneval, P. G. Camici, F. Christ, D. Henrion, B. I. Levy, A. Pries, and J.-L. Vanoverschelde
Evaluation of the microcirculation in hypertension and cardiovascular disease
Eur. Heart J., December 1, 2007; 28(23): 2834 - 2840.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Kim, A. S. Popel, M. Intaglietta, and P. C. Johnson
Aggregate formation of erythrocytes in postcapillary venules
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H584 - H590.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. A. Baumgartner Jr., A. J. Peterson, R. G. Presson Jr., N. Tanabe, E. M. Jaryszak, and W. W. Wagner Jr.
Blood flow switching among pulmonary capillaries is decreased during high hematocrit
J Appl Physiol, August 1, 2004; 97(2): 522 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Bishop, P. R. Nance, A. S. Popel, M. Intaglietta, and P. C. Johnson
Relationship between erythrocyte aggregate size and flow rate in skeletal muscle venules
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H113 - H120.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online