| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Cardiovascular Diseases, Departments of Anesthesiology, Pharmacology, and Medicine, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226
Recent evidence indicates that hyperglycemia is an important risk factor for the development of cardiovascular disease. We tested the hypothesis that myocardial infarct size is related to blood glucose concentration in the presence or absence of ischemic preconditioning (PC) stimuli in canine models of diabetes mellitus and acute hyperglycemia. Barbiturate-anesthetized dogs were subjected to a 60-min period of coronary artery occlusion and 3-h reperfusion. Infarct size was 24 ± 2% of the area at risk (AAR) for infarction in control dogs. PC significantly (P < 0.05) decreased the extent of infarction in normal (8 ± 2% of AAR), but not diabetic (22 ± 4% of AAR), dogs. Infarct size was linearly related to blood glucose concentration during acute hyperglycemia (r = 0.96; P < 0.001) and during diabetes (r = 0.74; P < 0.002) in the presence or absence of PC stimuli. Increases in serum osmolality caused by administration of raffinose (300 g) did not increase infarct size (11 ± 3% of AAR) or interfere with the ability of PC to protect against infarction (2 ± 1% of AAR). The results indicate that hyperglycemia is a major determinant of the extent of myocardial infarction in the dog.
diabetes mellitus; myocardial infarction
This article has been cited by other articles:
|
|
 |
|
  M. Engoren, A. Zacharias, R. H. Habib, T. A. Schwann, C. J. Riordan, S. J. Durham, and A. Shah The effect of diabetic medications on creatine kinase-myocardial band levels in patients undergoing coronary artery bypass surgery Interactive CardioVascular and Thoracic Surgery, November 1, 2009; 9(5): 793 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Peart and J. P. Headrick Clinical cardioprotection and the value of conditioning responses Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1705 - H1720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Anantharaman, M Heatley, and C F M Weston Hyperglycaemia in acute coronary syndromes: risk-marker or therapeutic target? Heart, May 1, 2009; 95(9): 697 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, V. E. Laubach, B. A. French, and I. L. Kron Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating nicotinamide adenine dinucleotide phosphate oxidase during reperfusion. J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 723 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Takahashi, Y Hiasa, Y Ohara, S Miyazaki, K Mahara, R Ogura, H Miyajima, K Yuba, N Suzuki, S Hosokawa, et al. Acute hyperglycaemia prevents the protective effect of pre-infarction angina on microvascular function after primary angioplasty for acute myocardial infarction Heart, November 1, 2008; 94(11): 1402 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ascione, C.A. Rogers, C. Rajakaruna, and G.D. Angelini Inadequate Blood Glucose Control Is Associated With In-Hospital Mortality and Morbidity in Diabetic and Nondiabetic Patients Undergoing Cardiac Surgery Circulation, July 8, 2008; 118(2): 113 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Huhn, A. Heinen, N. C. Weber, M. W. Hollmann, W. Schlack, and B. Preckel Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability transition pore Br. J. Anaesth., April 1, 2008; 100(4): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Weston, L Walker, J Birkhead, and National Audit of Myocardial Infarction Project, N Early impact of insulin treatment on mortality for hyperglycaemic patients without known diabetes who present with an acute coronary syndrome Heart, December 1, 2007; 93(12): 1542 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhong and D. H. Wang TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1791 - H1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Gross, A. K. Hsu, and G. J. Gross Diabetes Abolishes Morphine-Induced Cardioprotection via Multiple Pathways Upstream of Glycogen Synthase Kinase-3{beta} Diabetes, January 1, 2007; 56(1): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hassouna, M. Loubani, B. M. Matata, A. Fowler, N. B. Standen, and M. Galinanes Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium Cardiovasc Res, February 1, 2006; 69(2): 450 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tsang, D. J. Hausenloy, M. M. Mocanu, R. D. Carr, and D. M. Yellon Preconditioning the Diabetic Heart: The Importance of Akt Phosphorylation Diabetes, August 1, 2005; 54(8): 2360 - 2364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. LaDisa Jr., J. G. Krolikowski, P. S. Pagel, D. C. Warltier, and J. R. Kersten Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H601 - H607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Solomon, N. S. Anavekar, S. Greaves, J. L. Rouleau, C. Hennekens, M. A. Pfeffer, and HEART Investigators Angina pectoris prior to myocardial infarction protects against subsequent left ventricular remodeling J. Am. Coll. Cardiol., May 5, 2004; 43(9): 1511 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Gross, J. F. LaDisa Jr., D. Weihrauch, L. E. Olson, T. T. Kress, D. A. Hettrick, P. S. Pagel, D. C. Warltier, and J. R. Kersten Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1552 - H1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanaka, F. Kehl, W. Gu, J. G. Krolikowski, P. S. Pagel, D. C. Warltier, and J. R. Kersten Isoflurane-induced preconditioning is attenuated by diabetes Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2018 - H2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Lell, V. G. Nielsen, D. C. McGiffin, F. E. Schmidt Jr, J. K. Kirklin, and A. W. Stanley Jr Glucose-insulin-potassium infusion for myocardial protection during off-pump coronary artery surgery Ann. Thorac. Surg., April 1, 2002; 73(4): 1246 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kersten, W. G. Toller, J. P. Tessmer, P. S. Pagel, and D. C. Warltier Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2097 - H2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramasamy, J. A. Payne, J. Whang, S. R. Bergmann, and S. Schaefer Protection of ischemic myocardium in diabetics by inhibition of electroneutral Na+-K+-2Cl{-} cotransporter Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H515 - H522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kersten, M. W. Montgomery, T. Ghassemi, E. R. Gross, W. G. Toller, P. S. Pagel, and D. C. Warltier Diabetes and hyperglycemia impair activation of mitochondrial KATP channels Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1744 - H1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanaka, F. Kehl, W. Gu, J. G. Krolikowski, P. S. Pagel, D. C. Warltier, and J. R. Kersten Isoflurane-induced preconditioning is attenuated by diabetes Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2018 - H2023. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
