| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0618
Clinical and
experimental studies have shown that myocardial dysfunction is an early
event during endotoxemia or septic shock. Several reports have shown
that rodents submitted to a mild heat shock become resistant to
lipopolysaccharides (LPS) or sepsis. The most abundant of the heat
shock proteins (HSP), the HSP70, has been postulated to be the
principal mediator of the observed protection against endotoxemia. We
have tested the hypothesis that a protective effect against endotoxemia
is achievable by the increased presence of the HSP70 in rodent
cardiomyocytes. We have found that a transgenic mouse line
overexpressing the rat HSP70 gene in the heart exhibits an
increased tolerance to LPS treatment {control estimated survival
function [
(t)] = 0.538, transgenic (t) = 0.787, P < 0.05}. Interestingly, the increased presence of the HSP70 in the
hearts of these mice results in a decrease in the activation of the
inducible nitric oxide synthase (iNOS) after LPS treatment. We conclude
that HSP70 protection against LPS is most probably mediated through the
modulation of iNOS activation and the subsequent decreased synthesis of
nitric oxide in cardiomyocytes.
heat shock proteins; lipopolysaccharides; septic shock; crossprotection
This article has been cited by other articles:
|
|
 |
|
  J. P. McClung, J. D. Hasday, J.-r. He, S. J. Montain, S. N. Cheuvront, M. N. Sawka, and I. S. Singh Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R185 - R191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lawler, H.-B. Kwak, W. Song, and J. L. Parker Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1756 - R1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Manukhina, H. F. Downey, and R. T. Mallet Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Experimental Biology and Medicine, April 1, 2006; 231(4): 343 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Johnson and M. Fleshner Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72 J. Leukoc. Biol., March 1, 2006; 79(3): 425 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Luo, X. Sun, E. Hungness, and P.-O. Hasselgren Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-kappa B Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1193 - R1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Scharte, H. A. Baba, H. Van Aken, C. Schulzki, J. Meyer, C. Goeters, and H.-G. Bone Alanyl-Glutamine Dipeptide Does Not Affect Hemodynamics despite a Greater Increase in Myocardial Heat Shock Protein 72 Immunoreactivity in Endotoxemic Sheep J. Nutr., May 1, 2001; 131(5): 1433 - 1437. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
