Blood pressure and continuous electrocardiogram recordings were obtained from 12 participants during spontaneous breathing (SB1), dynamic handgrip exercise at 20% (HG₂₀) of maximal voluntary contraction (MVC), and spontaneous breathing (SB2) and dynamic handgrip exercise at 60% (HG₆₀) of MVC. Repeated-measures ANOVAs were used to examine the effects of the exercise conditions on mean arterial pressure (MAP), on mean standard deviation (SDNN), and on the coefficient of variation of R-R intervals. The mean R-R interval responded to exercise in an intensity-dependent manner. SDNN decreased with exercise but was not intensity dependent. Coefficient of variation decreased during HG₂₀, and MAP increased following HG₆₀. These data are consistent with the notion that changes in cardiovascular function with low-intensity exercise are primarily mediated by parasympathetic withdrawal, and as exercise intensity increases, additional cardiovascular reactivity is mediated by increased sympathetic outflow. The change in the coefficient of variation from rest to exercise was unique in comparison to the changes in SDNN, and this merits further investigation.