AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 278: H1916-H1923, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, K. D.
Right arrow Articles by Sarelius, I. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, K. D.
Right arrow Articles by Sarelius, I. H.
Vol. 278, Issue 6, H1916-H1923, June 2000

Remote arteriolar dilations in response to muscle contraction under capillaries

Kenneth D. Cohen, Bradley R. Berg, and Ingrid H. Sarelius

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

In hamster cremaster muscle, it has been shown previously that contraction of skeletal muscle fibers underlying small groups of capillaries (modules) induces dilations that are proportional to metabolic rate in the two arteriolar generations upstream of the stimulated capillaries (Berg BR, Cohen KD, and Sarelius IH. Am J Physiol Heart Circ Physiol 272: H2693-H2700, 1997). These remote dilations were hypothesized to be transmitted via gap junctions and not perivascular nerves. In the present study, halothane (0.07%) blocked dilation in the module inflow arteriole, and dilation in the second arteriolar generation upstream, the branch arteriole, was blocked by both 600 mosM sucrose and halothane but not tetrodotoxin (2 µM). Dilations in both arterioles were not blocked by the gap junction uncoupler 18-beta -glycyrrhetinic acid (40 µM), and 80 mM KCl did not block dilation of the module inflow arteriole. These data implicate a gap junctional-mediated pathway insensitive to 18-beta -glycyrrhetinic acid in dilating the two arterioles upstream of the capillary module during "remote" muscle contraction. Dilation in the branch arteriole, but not the module inflow arteriole, was attenuated by 100 µM Nomega -nitro-L-arginine. Thus selective contraction of muscle fibers underneath capillaries results in dilations in the upstream arterioles that have characteristics consistent with a signal that is transmitted along the vessel wall through gap junctions, i.e., a conducted vasodilation. The observed insensitivities to 18-beta -glycyrrhetinic acid, to KCl, and to Nomega -nitro-L-arginine suggest, however, that there are multiple signaling pathways by which remote dilations can be initiated in these microvessels.

microcirculation; cell signaling; conducted dilation; gap junctions


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
J. Berwick, D. Johnston, M. Jones, J. Martindale, C. Martin, A. J. Kennerley, P. Redgrave, and J.E.W. Mayhew
Fine Detail of Neurovascular Coupling Revealed by Spatiotemporal Analysis of the Hemodynamic Response to Single Whisker Stimulation in Rat Barrel Cortex
J Neurophysiol, February 1, 2008; 99(2): 787 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. E. Bearden, E. Linn, B. S. Ashley, and R. C. Looft-Wilson
Age-related changes in conducted vasodilation: effects of exercise training and role in functional hyperemia
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1717 - R1721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Mabanta, P. Valane, J. Borne, and M. D. Frame
Initiation of remote microvascular preconditioning requires KATP channel activity
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H264 - H271.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. E. Tschakovsky and D. D. Sheriff
Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation
J Appl Physiol, August 1, 2004; 97(2): 739 - 747.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
C. de Wit
Connexins Pave the Way for Vascular Communication
Physiology, June 1, 2004; 19(3): 148 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Duza and I. H. Sarelius
Increase in endothelial cell Ca2+ in response to mouse cremaster muscle contraction
J. Physiol., March 1, 2004; 555(2): 459 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. de Wit, F. Roos, S.-S. Bolz, and U. Pohl
Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion
Physiol Genomics, April 16, 2003; 13(2): 169 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Xu, R. A. Santizo, V. L. Baughman, and D. A. Pelligrino
ADP-induced pial arteriolar dilation in ovariectomized rats involves gap junctional communication
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1082 - H1091.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Oku, T. Kodama, K. Sakagami, and D. G. Puro
Diabetes-Induced Disruption of Gap Junction Pathways within the Retinal Microvasculature
Invest. Ophthalmol. Vis. Sci., July 1, 2001; 42(8): 1915 - 1920.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online