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Am J Physiol Heart Circ Physiol 278: H1941-H1947, 2000;
0363-6135/00 $5.00
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Vol. 278, Issue 6, H1941-H1947, June 2000

Effects of estrogen on venous function in rats with chronic heart failure

Ali Akbar Nekooeian and Catherine C. Y. Pang

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

The effect of 17beta -estradiol on venous function was investigated in ovariectomized rats with heart failure. Rats (50-60 days old) were ovariectomized and implanted with 60-day-release pellets that contain 17beta -estradiol (1.5 mg) or vehicle. The left coronary artery was ligated 7 days later. Another group of ovariectomized rats was given vehicle pellets and then a sham operation was performed. The rats were studied while under pentobarbital anesthesia at 7 wk after ligation. Ligated rats, relative to sham groups, had lower mean arterial pressure (MAP, -34 mmHg) and cardiac output (CO, -38%); higher arterial resistance (RA, +12%) and venous resistance (RV, +116%); mean circulatory filling pressure (MCFP, +40%) and left ventricular end-diastolic pressure (LVEDP, +11 mmHg); and similar cardiovascular responses to norepinephrine (NE). Treatment of ligated rats with 17beta -estradiol increased CO (+16%); reduced RA (-16%), RV (-35%), MCFP (-23%), and LVEDP (-3 mmHg); and augmented MAP, RV, and MCFP responses to NE. Therefore, 17beta -estradiol reduced MCFP, and this reduced preload (LVEDP). 17beta -Estradiol decreased RV, which, along with decreased RA (afterload), led to an increase in CO. 17beta -Estradiol likely augmented vasoconstriction to NE through an improvement on the cardiovascular status.

estradiol; mean circulatory filling pressure; arterial resistance; venous resistance; cardiac output; norepinephrine


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