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Department of Veterans Affairs Western New York Health Care System, Buffalo 14215; and the Departments of Medicine and Physiology at the State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214
Fasting [18F]fluoro-2-deoxyglucose (FDG) uptake
is increased in viable, chronically dysfunctional myocardium, but the
relationship to acute episodes of ischemia remains undefined.
To investigate FDG uptake in acute stunning, chronically instrumented
pigs (n = 9) and sham controls (n = 8)
were studied while in a fasted, closed-chest, anesthetized state.
One-hour partial occlusion reduced subendocardial flow from 1.24 ± 0.14 to 0.35 ± 0.06 ml · min
1 · g
1 and wall thickening from 16.8 ± 2.1 to 3.7 ± 0.7%. Regional function remained depressed during reperfusion
(8.3 ± 1.4%) despite the return of flow to resting levels.
Triphenyl tetrazolium chloride staining showed no irreversible injury.
FDG uptake in stunned myocardium was variably increased and averaged
1.5-fold higher than that of normal regions, with no consistent
transmural variation. Subgroup analysis showed that variability in FDG
uptake was related to alterations in insulin levels that varied
directly with ischemic risk region.
glycolysis; ischemia; regional blood flow; reperfusion; [18F] fluoro-2-deoxyglucose
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