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Am J Physiol Heart Circ Physiol 279: H216-H224, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 1, H216-H224, July 2000

Maturation of end-systolic stress-strain relations in chick embryonic myocardium

Kimimasa Tobita and Bradley B. Keller

Cardiovascular Development Research Program, Department of Pediatrics, University of Kentucky, Lexington, Kentucky 40536

The embryonic myocardium increases functional performance geometrically during cardiac morphogenesis. We investigated developmental changes in the in vivo end-systolic stress-strain relations of embryonic chick myocardium in stage 17, 21, and 24 white Leghorn chick embryos (n = 10 for each stage). End-systolic stress-strain relations were linear in all developmental stages. End-systolic strain decreased from 0.50 ± 0.02 to 0.31 ± 0.01 (mean ± SE, P < 0.05), while average end-systolic wall stress was similar at 3.29 ± 0.34 to 4.19 ± 0.43 mmHg (P = 0.14) from stage 17 to 24. Normalized end-systolic myocardial stiffness, a load-independent index of ventricular contractility, increased from 2.98 ± 0.19 to 6.03 ± 0.39 mmHg from stage 17 to 24 (P < 0.05). Zero-stress midwall volume increased from 0.024 ± 0.002 to 0.124 ± 0.004 µl from stage 17 to 24 (P < 0.05). These results suggest that the embryonic ventricle increases normalized ventricular "contractility" while maintaining average end-systolic wall stress over a relatively narrow range during cardiovascular morphogenesis.

embryonic ventricle; cardiovascular development; end-systolic wall stress; end-systolic wall strain; contractility


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 Am. J. Physiol. Heart Circ. Physiol.Home page
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Am J Physiol Heart Circ Physiol, July 1, 2001; 281 (1): H463 - H466.
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 Am. J. Physiol. Heart Circ. Physiol.Home page
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Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1248 - H1254.
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