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1-integrin in
vascular smooth muscle cells and alters adhesion to
fibronectin
Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
Retinoic
acid has an established physiological role in differentiation,
development, and cellular growth. This study investigated the action of
all-trans retinoic acid (ATRA) on vascular integrins, cell-surface receptors that control growth and remodeling of blood vessels. The 
1-integrin subunit mRNA and protein was
induced after treatment with ATRA in two different rat vascular smooth muscle cell lines. To relate this result to the in vivo state, the
aortas from adult rats fed with therapeutic doses of ATRA were examined
for 1-integrin protein. A significant upregulation of
the integrin subunit was observed in vivo. To assess if this increase
contributed to physiological changes in cellular function, cells
treated with ATRA were tested for alterations in adhesion to
extracellular matrix proteins. The cells exposed to the retinoid were
seen to adhere more strongly to fibronectin, via the
1-integrin. These results showed that modulation of
vascular integrins by ATRA in adult rats contributes to functional
changes that can cause remodeling of blood vessels.
all-trans retinoic acid; cell-adhesion molecules; rat blood vessels
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