AJP - Heart AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 279: H47-H57, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bishop, J. J.
Right arrow Articles by Johnson, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bishop, J. J.
Right arrow Articles by Johnson, P. C.
Vol. 279, Issue 1, H47-H57, July 2000

Diameter changes in skeletal muscle venules during arterial pressure reduction

Jeffrey J. Bishop1, Patricia R. Nance1, Aleksander S. Popel2, Marcos Intaglietta1, and Paul C. Johnson1

1 Department of Bioengineering, University of California, San Diego, La Jolla, California 92093; and 2 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205

Previous studies in skeletal muscle have shown a substantial (>100%) increase in venous vascular resistance with arterial pressure reduction to 40 mmHg, but a microcirculatory study showed no significant venular diameter changes in the horizontal direction during this procedure. To examine the possibility of venular collapse in the vertical direction, a microscope was placed horizontally to view a vertically mounted rat spinotrapezius muscle preparation. We monitored the diameters of venules (mean diameter 73.8 ± 37.0 µm, range 13-185 µm) oriented horizontally and vertically with a video system during acute arterial pressure reduction by hemorrhage. Our analysis showed small but significant (P < 0.0001) diameter reductions of 1.0 ± 2.5 µm and 1.8 ± 3.1 µm in horizontally and vertically oriented venules, respectively, upon reduction of arterial pressure from 115.0 ± 26.3 to 39.8 ± 12.3 mmHg. The venular responses were not different after red blood cell aggregation was induced by Dextran 500 infusion. We conclude that diameter changes in venules over this range of arterial pressure reduction are isotropic and would likely increase venous resistance by <10%.

venous resistance; venous pressure; venous collapse; venous wall architecture; hemorrhage


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
B. J. Behnke, D. J. Padilla, L. F. Ferreira, M. D. Delp, T. I. Musch, and D. C. Poole
Effects of arterial hypotension on microvascular oxygen exchange in contracting skeletal muscle
J Appl Physiol, March 1, 2006; 100(3): 1019 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Kim, A. S. Popel, M. Intaglietta, and P. C. Johnson
Effect of erythrocyte aggregation at normal human levels on functional capillary density in rat spinotrapezius muscle
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H941 - H947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Bishop, P. R. Nance, A. S. Popel, M. Intaglietta, and P. C. Johnson
Relationship between erythrocyte aggregate size and flow rate in skeletal muscle venules
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H113 - H120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Bishop, A. S. Popel, M. Intaglietta, and P. C. Johnson
Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H939 - H950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Bishop, P. R. Nance, A. S. Popel, M. Intaglietta, and P. C. Johnson
Erythrocyte margination and sedimentation in skeletal muscle venules
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H951 - H958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Bishop, P. R. Nance, A. S. Popel, M. Intaglietta, and P. C. Johnson
Effect of erythrocyte aggregation on velocity profiles in venules
Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H222 - H236.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online