| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Hypertension Clinic, Erasme Hospital, 1070 Brussels, Belgium; 2 Centro Ricerche Cardiovascolari, Medicina Interna II, Ospedale L. Sacco, Università degli studi di Milano, 20157 Milano, Italy; 3 Department of Hypertension and Diabetology, Medical University of Gdansk, 80-158 Gdansk, Poland; and 4 Divisions of Hypertension and Cardiology, Mayo Clinic, Rochester, Minnesota 55902
Interactions between
mechanisms governing ventilation and blood pressure (BP) are not well
understood. We studied in 11 resting normal subjects the effects of
sustained isocapnic hyperventilation on arterial baroreceptor
sensitivity, determined as the 
index between oscillations in
systolic BP (SBP) generated by respiration and oscillations present in
R-R intervals (RR) and in peripheral sympathetic nerve traffic [muscle
sympathetic nerve activity (MSNA)]. Tidal volume increased from
478 ± 24 to 1,499 ± 84 ml and raised SBP from 118 ± 2 to 125 ± 3 mmHg, whereas RR decreased from 947 ± 18 to
855 ± 11 ms (all P < 0.0001); MSNA did not
change. Hyperventilation reduced arterial baroreflex sensitivity to
oscillations in SBP at both cardiac (from 13 ± 1 to 9 ± 1 ms/mmHg, P < 0.001) and MSNA levels (by 
37 ± 5%, P < 0.0001). Thus increased BP during hyperventilation
does not elicit any reduction in either heart rate or MSNA. Baroreflex
modulation of RR and MSNA in response to hyperventilation-induced BP
oscillations is attenuated. Blunted baroreflex gain during
hyperventilation may be a mechanism that facilitates simultaneous
increases in BP, heart rate, and sympathetic activity during dynamic
exercise and chemoreceptor activation.
ventilation; sinus node
This article has been cited by other articles:
|
|
 |
|
  R. D. Thijs, J. G. van den Aardweg, R. H. A. M. Reijntjes, J. G. van Dijk, and J. J. van Lieshout Contrasting effects of isocapnic and hypocapnic hyperventilation on orthostatic circulatory control J Appl Physiol, October 1, 2008; 105(4): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Hunt, R. Tamisier, G. S. Gilmartin, M. Curley, A. Anand, and J. W. Weiss Baroreflex responsiveness during ventilatory acclimatization in humans Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1794 - H1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Simmons, J. M. Manson, and J. R. Halliwill Mild central chemoreflex activation does not alter arterial baroreflex function in healthy humans J. Physiol., September 15, 2007; 583(3): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Stewart, M. S. Medow, N. S. Cherniack, and B. H. Natelson Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H904 - H913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Narkiewicz, P. van de Borne, N. Montano, D. Hering, T. Kara, and V. K. Somers Sympathetic Neural Outflow and Chemoreflex Sensitivity Are Related to Spontaneous Breathing Rate in Normal Men Hypertension, January 1, 2006; 47(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kamiya, T. Kawada, K. Yamamoto, D. Michikami, H. Ariumi, T. Miyamoto, S. Shimizu, K. Uemura, T. Aiba, K. Sunagawa, et al. Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2641 - H2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. T. Leung, M. E. Bowman, T. M. Diep, G. Lorenzi-Filho, J. S. Floras, and T. D. Bradley Influence of Cheyne-Stokes respiration on ventricular response to atrial fibrillation in heart failure J Appl Physiol, November 1, 2005; 99(5): 1689 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Rutherford, T. H. Clutton-Brock, and M. J. Parkes Hypocapnia reduces the T wave of the electrocardiogram in normal human subjects Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R148 - R155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Costes, F. Roche, V. Pichot, J.M. Vergnon, M. Garet, and J-C. Barthelemy Influence of exercise training on cardiac baroreflex sensitivity in patients with COPD Eur. Respir. J., March 1, 2004; 23(3): 396 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fietze, D. Romberg, M. Glos, S. Endres, H. Theres, C. Witt, and V. K. Somers Effects of positive-pressure ventilation on the spontaneous baroreflex in healthy subjects J Appl Physiol, March 1, 2004; 96(3): 1155 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Cooper, T. H. Clutton-Brock, and M. J. Parkes Contribution of the respiratory rhythm to sinus arrhythmia in normal unanesthetized subjects during positive-pressure mechanical hyperventilation Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H402 - H411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Muenter Swift, M. J. Cutler, P. J. Fadel, W. L. Wasmund, S. Ogoh, D. M. Keller, P. B. Raven, and M. L. Smith Carotid baroreflex function during and following voluntary apnea in humans Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2411 - H2419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Lanfranchi and V. K Somers Arterial baroreflex function and cardiovascular variability: interactions and implications Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R815 - R826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. van de Borne, J. Neubauer, M. Rahnama, J.-L. Jansens, N. Montano, A. Porta, V. K. Somers, and J. P. Degaute Differential Characteristics of Neural Circulatory Control: Early Versus Late After Cardiac Transplantation Circulation, October 9, 2001; 104(15): 1809 - 1813. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
